Mohamed Zaki

A number of 2-substituted and 2,3-disubstitutedquinazolinone analogues have been synthesized. Their structures have been elucidated on the basis of elemental analyses and spectroscopic studies (IR, 1H NMR, and MS). An evaluation of the anticonvulsant activity of the prepared compounds has indicated that some of them exhibit moderate to significant activity, compared to diazepam and phenobarbital standards.

Two series of novel non acidic 3, 5-diarylpyrazoline and 3, 5-diarylisoxazoline derivatives were designed to be synthesized and screened for anti-inflammatory and analgesic activities. In addition, molecular modelling and docking of the designed compounds into cyclooxygenase II (COX-II) using Molsoft ICM 3.4-8C program was performed in order to predict the affinity and orientation of the designed compounds at the active site compared with its binding inhibitor celecoxib. The ICM score values show good agreement with predicted binding affinities,

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Mycoplasmae have the ability to colonize the respiratory and reproductive tracts of bovine. Consequently, these microorganisms can be associated with infertility and pneumonia. A total of 555 cows and 130 buffalo's samples (nasal swabs, lung tissues, tracheal swabs, bronchial lymph nodes and vaginal swabs) was collected from different Egyptian governorates and investigated. Mycoplasmaisolates collected from the respiratory tract of cattle and buffaloes were typed as M. bovis(2.7 and 1.7%, respectively) and other Mycoplasma species (10.8 and 4.2%, respectively). M. boviswas typed from vaginal swabs of the examined cows and buffaloes with incidence of 2.2 and 10 %, respectively, while the incidence of M. bovigenitaliumwas 13.3 and 10 %, respectively. Treatment of Mycoplasma diseases is difficult since Mycoplasma species lack a cell wall and are thus resistant to some commonly used antibiotics. Exposure of M. bovisand M. bovigenitaliumisolates to 1.1Ie against five antibiotics including erythromycin, gentamicin, tetracycline, streptomycin and lincomycin in comparison to reference strains revealed that lincomycin, erythromycin and streptomycin are more effective and able to get rid of M. bovisand M. bovigenitalium.