Mohamed Zaki

Objectives: To assess the effects of a 4-week levofloxacin course on PSA in asymptomatic men with elevated prostate-specific antigen (PSA) and on prostate biopsy decision.

The antioxidant activity of water extracts (cold and hot) of six caffeine products were carried out. The extracts were screened for total polyphenol contents and antioxidant activity using DPPH, ABTS methods and reducing power method at 50 and 100 ?g/ml after 15 and 30 min using BHA and Caffeine as standard compounds. The results indicated that, the hot water extracts for different caffeine products showed high antioxidant activity more than cold extracts and this activity was time and concentration dependent. In addition, the activity was higher against ABTS radical more than DPPH and reducing power methods. Also, there is positive correlation between the antioxidant and reducing compounds presented in water extracts of different caffeine products. The results of HPLC showed that fresh tea leaves are rich in flavanol monomers known as catechins. The most abundant catechin derivatives in green tea are EGC, EGCG and GC. On the other hand, EGCG and GC are major catechin derivative in different caffeine product except El-Fakher tea and Cacao. Generally, these beverages had high antioxidant capacities and total phenolic contents and could be important dietary sources of antioxidant phenolic for prevention of diseases caused by oxidative stress.

The objective of the present study was to investigate the antioxidant and immunostimulating activities of two yeast autolysates (baker's yeast and active dry yeast) using various methods. In this study, total glutathione content was determined in both yeast autolysates. Antioxidant activity of both yeast autolysates was evaluated by various assays, including total antioxidant capacity, reducing power, DPPH radical scavenging, nitric oxide scavenging, hydroxyl radical scavenging and metal ion chelating activities. The immunostimulating activity of both yeast autolysates was evaluated using rat splenocyte proliferation by the colorimetric MTT assay.

The objectives of the present study are to eva-luate the chromosomal aberrations in somatic and germ cells of alloxanized diabetic rats treated with methanolic extracts of Cleome droserifolia (Sammo),

This study aimed to investigate the antitumor effects of Ecbalium elaterium (squirting cucumber) (Cucurbitaceae) fruit juice and some fruit extracts as well as bee honey separately and in mixture. The fruit juice of E. elaterium, which is found to be rich in cucarbitacins, was selected for further evaluation of antitumor activity on the bases of a phytochemical study by thin layer chromatographic technique (TLC). The antitumor effects of the fruit juice and bee honey (separately and in mixture) were assessed for human brain tumor cell line (U251) using trypan blue exclusion assay for evaluating cytotoxicity, and H3-thymidine assay for estimating DNA synthesis. ELISA technique for measuring cell cycle regulation and the evaluation of the effects on metastasis and angiogenesis were also achieved. Results suggested that honey did not inhibit tumor cell growth through cyclin D1, P21 regulation or cell number reduction but through a significant inhibition of DNA synthesis. Results showed that E. elaterium fruit juice significantly down regulated P21, up-regulated cyclin D1, decreased cell number and inhibited DNA synthesis. Mixing of honey with E. elaterium fruit juice decreased the cytotoxicity induced by the latter and produced intermediate inhibition of DNA synthesis and down regulation of P21. All treatments inhibited MMP2 and MMP9. Thus, honey was able to reduce the cytotoxic effect of E. elaterium juice on glioblastoma cells enhancing its ability of inhibiting DNA synthesis and they acting together as antiangiogenic and antimetastatic agents.

An absolute parallelism (AP-) space having Finslerian properties is called FAP-space. This FAP-structure is wider than both conventional AP and Finslerstructures. In the present work, more geometric objects as curvature and torsiontensors are derived in the context of this structure. Also second order tensors,usually needed for physical applications, are derived and studied. Furthermore,the anti-curvature and the W-tensor are defned for the FAP-structure. Relationsbetween Riemannian, AP, Finsler and FAP structures are given.