Mohamed Zaki

n/a

E-Learning has been increasingly used as a medium for promoting health awareness with successful outcomes. This paper reports on the design and evaluation of prototype that uses the potential of E-Learning to help children with diabetes. The pedagogical principle of the proposed prototype is raising the diabetes awareness among young children. The prototype evaluation results indicated that computer-based learning can generate positive learning and motivational attitudes in children. Children who were educated through the prototype were able to complete awareness tasks faster than those who were educated using traditional methods. The prototype has been found makes learning more fun, and allows children to learn at their own pace.

With the widespread and increasing use of internet and digital forms of image; and the convencience of medical professionals that the future of health care will be shaped by teleradiology and technologies such as telemedicine in general. In addition to the various radiological modalities which produce a variety of digital medical files most often datasets and images. These files should be protected from unwanted modification of their contents, especially as they contain vital medical information. Thus their protection and authentication seems to be of great importance and this need will rise along with the future standardization of exchange of data between hospitals or between patients and doctors. In this paper, an associative watermarking scheme is conducted to perform associative watermarking rules to the images which reducts the amount of embedded data, vector quantization indexing scheme is used to embed watermark for the purpose of image authentication. The vector quantization decoding technique is applied to reconstruct the watermarked image from the watermarked index table. The experimental results show that the proposed scheme is robust. The watermarked images are resistant to severe image processing attcks such as Gaussian noise, brightness, blurring, sharpening, cropping, and JPEG lossy compression.

n/a

Polycomb group proteins, which have well-established roles in gene regulation, were recently found to accumulate on chromatin surrounding DNA damage and to contribute up to 40 percent of the radiation resistance of cell lines. The oncogenic polycomb protein, BMI-1, was additionally shown to be essential for the increased radiation resistance observed in stem cells and cancer stem cells relative to their more differentiated counterparts. BMI-1, is a very early DNA damage response protein that accumulates through a $\gamma$H2AX/RNF8-independent, but poly(ADP-ribosyl)ation-dependent mechanism at DNA double-strand breaks. BMI-1 acts together with RING2 and other components of the PRC1 histone H2A E3 ubiquitin ligase to ubiquitylate histones H2A and H2AX in response to DNA damage. BMI-1 dependent ubiquitin modifications are at the base of an ubiquitin pathway that enhances radioresistance through the accumulation of RAP80, 53BP1, and BRCA1. Members of the PRC2 histone H3 lysine 27 methyltransferase complex are also recruited to sites of DSBs but it remains to be determined whether the histone methyltransferase and histone E3 ubiquitin ligase polycomb complexes function in concert or independently during DNA repair. Understanding the contribution of polycomb group proteins to the DNA damage response may lead to novel therapeutic strategies that increase the response of human cancers to therapies that work through DNA damage, while simultaneously sensitizing the cancer stem cell population that would otherwise lead to relapse