Publications

Export 63 results:
Sort by: Author Title Type [ Year (Desc)]
2015
Awadallah, F. M., S. M. Abou-Seri, M. M. Abdulla, and H. H. Georgey, "Design and synthesis of potent 1,2,4-trisubstituted imidazolinone derivatives with dual p38αMAPK and ERK1/2 inhibitory activity.", European journal of medicinal chemistry, vol. 94, pp. 397-404, 2015 Apr 13. Abstracthfs.pdf

The synthesis of new 1,2,4-trisubstituted imidazolinone derivatives was described. The new compounds were designed as dual p38αMAPK and ERK1/2 inhibitors through hybridization of pharmacophoric elements associated with inhibition of these kinases. The kinase inhibition assay revealed excellent activity in the nanomolar range; especially compounds 6d and 7h which seemed promising candidates for such dual activity with IC50 values of 4.5 and 4.7 nM against p38αMAP, 25.0 and 24.0 nM against ERK1, and 3.2 and 3.5 nM against ERK2, respectively. These compounds were further tested for their antiproliferative activity against nine cancer cell lines, where they elicited high activity in the sub-micromolar range against breast, prostate and melanoma cells.

Eldehna, W. M., M. Fares, H. S. Ibrahim, M. H. Aly, S. Zada, M. M. Ali, S. M. Abou-Seri, H. A. Abdel-Aziz, and D. A. E. A. Ella, "Indoline ureas as potential anti-hepatocellular carcinoma agents targeting VEGFR-2: Synthesis, in vitro biological evaluation and molecular docking", European Journal of Medicinal Chemistry, vol. 100, pp. 89-97, 2015. phu.pdf
2014
Hassan, G. S., S. M. Abou-Seri, G. Kamel, and M. M. Ali, "Celecoxib analogs bearing benzofuran moiety as cyclooxygenase-2 inhibitors: Design, synthesis and evaluation as potential anti-inflammatory agents", European Journal of Medicinal Chemistry, vol. 76, pp. 482-493, 2014. author_copy.pdf
Mohamed Faresa, S. M. Abou-Seri, H. A. Abdel-Aziz, S. E. - S. Abbas, M. M. Youssef, and R. Ahmed, "Synthesis and antitumor activity of pyrido [2,3-d]pyrimidine and pyrido[2,3-d] [1,2,4]triazolo[4,3-a]pyrimidine derivatives that induce apoptosis through G1 cell-cycle arrest", European Journal of Medicinal Chemistry, vol. 83 , pp. 155-166, 2014. faris.pdf
2013
Amin, K. M., A. A. M. Eissa, S. M. Abou-Seri, and F. M. Awadallah, "Synthesis and biological evaluation of novel coumarin-pyrazoline hybrids endowed with phenylsulfonyl moiety as antitumor agents", European Journal of Medicinal Chemistry, vol. 60, pp. 187-198, 2013.
2012
Taher, A. T., and S. M. Abou-Seri, "Synthesis and Bioactivity Evaluation of New 6-Aryl-5-cyano thiouracils as Potential Antimicrobial and Anticancer Agents", Molecules, vol. 17, pp. 9868-9886, 2012.
Abadi, A. H., S. M. Abou-Seri, Q. Hu, and M. Negri, "Synthesis and biological evaluation of imidazolylmethylacridones as cytochrome P-450 enzymes inhibitors", Med. Chem. Commun, vol. 3, pp. 663-666, 2012.
2011
Amin, K. M., F. M. Awadalla, A. A. M. Eissa, and S. M. Abou-Seri, "Design, synthesis and vasorelaxant evaluation of novel coumarin–pyrimidine hybrids", Bioorganic & Medicinal Chemistry , vol. 19, pp. 6087–6097, 2011.
Abou-Seri, S. M., K. Abouzid, and D. A. E. A. Ella, "Molecular modeling study and synthesis of quinazolinone-arylpiperazine derivatives as a1-adrenoreceptor antagonists", European Journal of Medicinal Chemistry , vol. 46 , pp. 647-658, 2011.
Abou-Seri, S. M., N. A. Farag, and G. S. Hassan, "Novel Diphenylamine 2,4-Dicarboxamide Based Azoles as Potential Epidermal Growth Factor Receptor Inhibitors: Synthesis and Biological Activity", Chem. Pharm. Bull. , vol. 59, issue 9, pp. 1124—1132, 2011.
Hassan, G. S., H. H. Kadry, S. M. Abou-Seri, and M. M. Ali, "Synthesis and in vitro cytotoxic activity of novel pyrazolo[3,4-d]pyrimidines and related pyrazole hydrazones toward breast adenocarcinoma MCF-7 cell line ", Bioorganic & Medicinal Chemistry, vol. 19 , pp. 6808–6817, 2011.
2010
Abou-Seri, S. M., "Synthesis and biological evaluation of novel 2,4'-bis substituted diphenylamines as anticancer agents and potential epidermal growth factor receptor tyrosine kinase inhibitors", European Journal of Medicinal Chemistry, vol. 45 , pp. 4113-4121, 2010.
2006
Abadi, A. H., S. M. Abou-Seri, D. E. Abdel-Rahman, and C. Klein, "Synthesis of 3-substituted-2-oxoindole analogues and their evaluation as kinase inhibitors, anticancer and antiangiogenic agents", European Journal of Medicinal Chemistry , vol. 41 , pp. 296–305, 2006.
Tourism