,
"Preparation and application of molecularly imprinted polymer for isolation of chicoric acid from Chicorium intybus L. medicinal plant",
Analytica Chimica Acta, vol. 877, pp. 80-89, 2015.
AbstractMolecularly imprinted polymer (MIP) was synthesized and applied for the extraction of chicoric acid
from Chicory herb (Chicorium intybus L.). A computational study was developed to
find a suitable
template to functional monomer molar ratio for MIP preparations. The molar ratio was chosen based on
the comparison of the binding energy of the complexes between the template and functional monomers.
Based on the computational results, eight different polymers were prepared using chicoric acid
as the template. The MIPs were synthesized in a non-covalent approach via thermal free-radical
polymerization, using two different polymerization methods, bulk and suspension. Batch rebinding
experiments were performed to evaluate the binding properties of the imprinted polymers. The best
results were obtained with a MIP prepared using bulk polymerization with 4-vinylpyridine (4-VP) as the
functional monomer and ethylene glycol dimethacrylate (EGDMA) as the crosslinker with a molar ratio of
1:4:20. The best MIP showed selective binding ability toward chicoric acid in the presence of the
template’s structural analogues, caffeic acid, caftaric acid and chlorogenic acid.
,
"Synthesis andapplicationofamolecularlyimprintedpolymerforthe voltammetricdeterminationoffamciclovir",
Biosensors andBioelectronics, vol. 65, pp. 108-114, 2015.
AbstractA molecularlyimprintedpolymer(MIP)wassynthesizedandappliedasadditivewithinacarbonpaste
electrode forthecyclicvoltammetricdeterminationoffamciclovir(FCV).Complementarycomputational
studies wereperformedtostudytheintermolecularinteractionsinthepre-polymerizationmixture.
Derivedfromthecomputationalstudies,fourMIPratiosweresynthesizedandtheirperformancewas
evaluatedusingequilibriumrebindingassays.TheMIPwiththehighestbindingcapacitywasselected.A
linear responsewasobtainedintherangeof2.5106–1.0103 M withalimitofdetectionat
7.5107 M. Finally,thedevelopedMIP–voltammetry systemwassuccessfullyappliedforthede-
termination ofFCVinpuresolutionsandpharmaceuticalpreparations.