Developing Computational Models for the Biomechanical Assessment of the Thoracolumbar Spine Surgeries
During my doctoral studies, I have developed skills in modeling and testing the biomechanical performance of implantable devices used in the treatment of different spine fractures and degenerative diseases; likewise, I have simulated the biomechanical implications of various spine surgeries in relation to the occupational activities of the patients. Such research required the use of several image analyses, CAD, and finite element (FE) tools to reconstruct 3D anatomic models from CT and MRI images. This research was performed in collaboration with the Max Biedermann Institute for Biomechanics, where we were performing spine surgeries on cadavers and used testing machines to evaluate spinal stiffness and intradiscal pressure on the adjacent segments. I worked with various orthopedic surgeons to understand the problems they are facing with the implantable devices used in spinal fusion, and to be able to replicate their surgeries in computer models to conduct specific testing protocols. In addition, I worked on developing FE models for the knee joint to investigate the effects of femoral notching, overstuff, and implant rotation in total knee arthroplasty.
Concurrently, I worked on developing a diffusive-reactive model of the intervertebral disc (IVD) to investigate the etiology of back pain. The model described the metabolism of the disc via chemical reactions, as well as the transport of the nutrients and growth factors to the IVD from the surrounding vascular network. This was used in multiple studies to understand the homeostasis in the IVD and the mechanics of disc degeneration due to cartilage endplate calcification, aging, and tobacco smoking. Moreover, I investigated the effectiveness of pro-anabolic treatments for IVD degeneration based on exogenous administration of growth factors. I also have a great experience in building musculoskeletal models, conducting intramuscular electromyography measurements and Video-motion analysis.
With this diverse experience, I have published eight refereed journal articles and fourteen conference posters, besides participating in funded proposal preparations. I was also fortunate to win the SPINE section award in the ORS 2016 and reaching the finalist in the ORS 2017.