EVALUATION OF THE PROTECTIVE VALUE OF SOME TOXOCARA VITULORUM ANTIGENS IN RATS

Citation:
Mahdy OA, Mousa WM, Maogood ASZ, Abel-Radi S. "EVALUATION OF THE PROTECTIVE VALUE OF SOME TOXOCARA VITULORUM ANTIGENS IN RATS." Egyptian Society of Parasitology. 2017;47: 293-301.

Abstract:

Toxocara vitulorum is a nematode parasite of small intestine of buffalo, particularly young age calves, causing high morbidity and mortality. The control of this infection produces considerable eco-nomic benefits. Immunization of Wistar rats with different T. vitulorum antigens; (execratory/ secreto-ry antigen (ESAg), peri-enteric fluid antigen (peAg) and embryonated eggs antigen (EEAg)) were evaluated for induction of protection against a challenge oral infection with embryonated eggs of T. vitulorum. It was found that peAg induce the highest protection level (100%) followed by ESAg (96.4%-97.5%) then EEAg (93.7%-96.7%). Mean number of larvae extracted from immunized rats was significantly (P≤ 0.05) lower than that extracted from the control non-immunized one. The num-ber of larvae collected after digestion of the liver at 3rd day post challenge (dp.c.) was decreased from 998.5 in control rats to 26 and 41.5 in rats immunized with ESAg and EEAg respectively. In the same time no significant (P≤0.05) difference in size of larvae extracted from immunized and control posi-tive rats. For conclusion, the study demonstrated the value of rats as experimental model for investiga-tion T. vitulorum infection. It characterized PeAg as a valuable immunogenic and protective antigen in minimize the infection by T. vitulorum between mother and calves in infected farms.

EVALUATION OF THE PROTECTIVE VALUE OF SOME TOXOCARA VITULORUM ANTIGENS IN RATS (PDF Download Available). Available from: https://www.researchgate.net/publication/323120328_EVALUATION_OF_THE_PROTECTIVE_VALUE_OF_SOME_TOXOCARA_VITULORUM_ANTIGENS_IN_RATS [accessed Mar 13 2018].

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