Ahmed, H. H., L. A. Rashed, S. M. Mahfouz, R. E. Hussein, M. A. Alkaffas, S. M. Abas, and A. A. Ahmed, "Can mesenchymal stem cells pretreated with platelet-rich plasma modulate tissue remodeling in a rat with burned skin?", Biochem. Cell Biol. , vol. 95, issue 5, pp. 537-548, 2017. bcb-2016-0224.pdf
Zaahkouk, A. M. S., A. M. T. Aziz, A. M. Rezq, H. M. Atta, H. H. Fouad, H. H. Ahmed, D. Sabry, and M. H. Yehia, "Efficacy of a novel water-soluble curcumin derivative versus sildenafil citrate in mediating erectile function.", International Journal of Impotence Research, vol. 27, pp. 9-15, 2014.
MT, A. A., R. AM, A. HM, F. H, Z. AM, A. HH, S. D, and Y. HM, "Molecular signalling of a novel curcumin derivative versus Tadalafil in erectile dysfunction.", Andrologia, vol. 6, issue 47, pp. 616-625, 2015. Abstract

The efficacy of a novel curcumin derivative (NCD) versus tadalafil in erectile signalling was assessed. Ten control male rats and 50 diabetic male rats were used and divided into the following: diabetic (DM), curcumin (CURC), NCD, tadalafil and NCD combined with tadalafil rat groups. Cavernous tissue gene expression of heme oxygenase-1 (HO-1), Nrf2, NF-B and p38, enzyme activities of heme oxygenase (HO) and nitric oxide synthase (NOS), cGMP and intracavernosal pressure (ICP)/mean arterial pressure (MAP) were assessed. Results showed that 12 weeks after induction of diabetes, erectile dysfunction (ED) was confirmed by the significant decrease in ICP/MAP, a significant decrease in cGMP, NOS, HO enzyme activities, a significant decrease in HO-1 gene and a significant increase in NF-Ҡβ, p38 genes. Administration of all therapeutic interventions led to a significant increase in ICP/MAP, cGMP levels, a significant increase in HO-1 and NOS enzymes, a significant increase in HO-1, and Nrf2 gene expression, and a significant decrease in NF-Ҡβ, p38 gene expression. NCD or its combination with tadalafil showed significant superiority and more prolonged duration of action. In conclusion, a tendency was observed that CURC and NCD have high efficacy and more prolonged duration of action in enhancing erectile function.