Abdelkader, N. F., N. M. Arafa, A. S. Attia, A. A. Ain-Shoka, and D. M. Abdallah, "Pyrrolidine dithiocarbamate ameliorates rotenone-induced Parkinson’s disease in rats", Bulletin of Faculty of Pharmacy, Cairo University, vol. 55, issue 1, pp. 107-113, 2017.
Ahmed, H. H., H. S. El-Abhar, E. A. K. Hassanin, N. F. Abdelkader, and M. B. Shalaby, "Ginkgo biloba L. leaf extract offers multiple mechanisms in bridling N-methylnitrosourea - mediated experimental colorectal cancer.", Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, vol. 95, pp. 387-393, 2017 Nov. Abstract

In Egypt, colorectal cancer (CRC) is the 6th cancer in both gender and CRC rates are high in subjects under 40 years of age. This study goaled to determine the development of CRC using relevant biochemical markers and to elucidate the potent mechanism of Ginkgo biloba L. leaf extract in retrogression of experimental CRC. Adult male Sprague-Dawley rats were administered N-methylnitrosourea (N-MNU; 2mg in 0.5ml water/rat) intrarectally thrice a week for five weeks to induce CRC, followed by treatment with either 5-fluorouracil (5-FU; 12.5mg/kg, i.p.) or Ginkgo biloba L. leaf extract in a dose of 0.675 and 1.35g/kg, p.o. respectively. The developed tumor enhanced plasma TGF-β, and Bcl2, serum EGF, CEA, CCSA, and MMP-7 significantly. Also, gene expression analysis showed significant upregulation of colonic β-Catenin, K-ras and C-myc genes. Besides, immunohistochemical findings revealed significant increase in COX-2, cyclin D1 and survivin content in colon tissue. These data were further supported by the histological observations. Ginkgo biloba L. leaf extract-treated rats; particularly those treated with dose of 1.35g/kg, exhibited significant reduction in the aforementioned parameters and improvement in the histological organization of the colon tissue. The therapeutic effect of Ginkgo biloba L. leaf extract was comparable with that mediated by 5-FU. The current research proved that Ginkgo biloba L. leaf extract could suppress tumor cell proliferation, promote apoptosis, and mitigat inflammation in vivo. The amelioration of these key events might be linked with the inhibition of Wnt/β-Catenin signaling module. The outcomes of the present investigation encourage the use of Ginkgo biloba L. leaf extract as a complementary and alternative therapeutic approach to abate CRC.

Ahmed, H. H., H. S. El-Abhar, E. A. K. Hassanin, N. F. Abdelkader, and M. B. Shalaby, "Ginkgo biloba L. leaf extract offers multiple mechanisms in bridling N-methylnitrosourea - mediated experimental colorectal cancer.", Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, vol. 95, pp. 387-393, 2017 Nov. Abstract

In Egypt, colorectal cancer (CRC) is the 6th cancer in both gender and CRC rates are high in subjects under 40 years of age. This study goaled to determine the development of CRC using relevant biochemical markers and to elucidate the potent mechanism of Ginkgo biloba L. leaf extract in retrogression of experimental CRC. Adult male Sprague-Dawley rats were administered N-methylnitrosourea (N-MNU; 2mg in 0.5ml water/rat) intrarectally thrice a week for five weeks to induce CRC, followed by treatment with either 5-fluorouracil (5-FU; 12.5mg/kg, i.p.) or Ginkgo biloba L. leaf extract in a dose of 0.675 and 1.35g/kg, p.o. respectively. The developed tumor enhanced plasma TGF-β, and Bcl2, serum EGF, CEA, CCSA, and MMP-7 significantly. Also, gene expression analysis showed significant upregulation of colonic β-Catenin, K-ras and C-myc genes. Besides, immunohistochemical findings revealed significant increase in COX-2, cyclin D1 and survivin content in colon tissue. These data were further supported by the histological observations. Ginkgo biloba L. leaf extract-treated rats; particularly those treated with dose of 1.35g/kg, exhibited significant reduction in the aforementioned parameters and improvement in the histological organization of the colon tissue. The therapeutic effect of Ginkgo biloba L. leaf extract was comparable with that mediated by 5-FU. The current research proved that Ginkgo biloba L. leaf extract could suppress tumor cell proliferation, promote apoptosis, and mitigat inflammation in vivo. The amelioration of these key events might be linked with the inhibition of Wnt/β-Catenin signaling module. The outcomes of the present investigation encourage the use of Ginkgo biloba L. leaf extract as a complementary and alternative therapeutic approach to abate CRC.

Ahmed, H. H., H. S. El-Abhar, E. A. Hassanin, N. F. Abdelkader, and M. B. Shalaby, "Punica granatum suppresses colon cancer through downregulation of Wnt/β-Catenin in rat model", Revista Brasileira de Farmacognosia, vol. 27, issue 5, pp. 627-635, 2017.
Abdelkader, N. F., M. A. Saad, and R. M. Abdelsalam, "Neuroprotective effect of nebivolol against cisplatin-associated depressive-like behavior in rats.", Journal of neurochemistry, vol. 141, issue 3, pp. 449-460, 2017 May. Abstract

One-third of cancer patients undergoing chemotherapy treatment often display symptoms of depression leading to poor adherence and decreased quality of life. Thus, this study aimed to investigate the possible protective effect of nebivolol against cisplatin-associated depressive symptoms in adult male rats. Nebivolol is a highly cardioselective β-adrenergic receptor blocker that possesses endothelium-dependent vasodilator properties and antioxidant capacities. Animals were allocated into four groups. Group one was given aqueous solution of carboxymethyl cellulose and served as control, group two was given nebivolol (10 mg/kg p.o., daily), group three was given cisplatin (2 mg/kg i.p. once per week) for 10 consecutive weeks and group four was treated with cisplatin concomitantly with nebivolol as per above schedule. Cisplatin-treated rats showed an increase in both depressive-like behaviors in open-field and forced swimming tests. In addition, histopathological examination revealed cortical encephalomalacia along with hippocampal neuronal degeneration and kidney dysfunction. In parallel, cisplatin administration prominently reduced GABA and elevated glutamate levels in the cortical and hippocampal tissues. Furthermore, it resulted in a significant decline in cortical and hippocampal brain-derived neurotrophic factor and nitric oxide contents concomitantly with a marked decrease in endothelial- and an increase in inducible-nitric oxide synthase genes expression. On the other hand, treatment with nebivolol effectively mitigated the aforementioned cisplatin-associated behavioral, biochemical, and histopathological alterations without changing its antitumor activity as evidenced by sulforhodamine B cell survival assay. Taken together, our results suggest that nebivolol may offer a promising approach for alleviating depressive symptoms associated with the use of cisplatin.

Eid, A. H., N. F. Abdelkader, O. M. Abd El-Raouf, H. M. Fawzy, and E. S. El-Denshary, "Carvedilol alleviates testicular and spermatological damage induced by cisplatin in rats via modulation of oxidative stress and inflammation", Arch. Pharm. Res., vol. 39, pp. 1693-1702, 2016.
KANDIL, E. A., N. F. Abdelkader, B. M. El-Sayeh, and S. Saleh, "Imipramine and amitriptyline ameliorate the rotenone model of Parkinson's disease in rats.", Neuroscience, vol. 332, pp. 26-37, 2016.
Abdelkader, N. F., M. M. Safar, and H. A. Salem, "Ursodeoxycholic Acid Ameliorates Apoptotic Cascade in the Rotenone Model of Parkinson’s Disease: Modulation of Mitochondrial Perturbations", Molecular Neurobiology, vol. 53, issue 2, pp. 810-817, 2016.
Abdelkader, N. F., Neuroprotection in Experimentally Induced Parkinson’s Disease in Rats, , Saarbrücken, Germany, LAP LAMBERT Academic Publishing, 2014. cover.pdfbook.pdf
Abd-El-Fattah, M. A., N. F. Abdelakader, and H. F. Zaki, "Pyrrolidine dithiocarbamate protects against scopolamine-induced cognitive impairment in rats", European Journal of Pharmacology, vol. 723, pp. 330-338, 2014. 330.pdf
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