El-Anwar, N., H. Bazaraa, S. T. Fayez, and Y. A. Fahmy, "Profile of renal conditions among pediatric emergency patients‏", Egyptian Pediatric Association Gazette, vol. 72, issue 1, pp. 99, 2024.
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Y, R., E. K. N, S. S, M. G, and E. - A. N, "Fatigue assessment and its predictors in pediatric patients with chronic kidney disease stages III to V", Egyptian Pediatric Association Gazette, pp. 1-5, 2023.
Bazaraa, H. M., H. I. Rady, S. A. Mohamed, W. A. Rabie, and N. H. ElAnwar, "Initial Response and Outcome of Critically Ill Children With Guillain Barre' Syndrome.", Frontiers in pediatrics, vol. 7, pp. 378, 2019. Abstract

Guillain-Barre syndrome is the most common cause of acute flaccid paralysis worldwide since the eradication of poliomyelitis. Severe cases may require intensive care and mechanical ventilation. was to study pediatric patients with severe GBS requiring intensive care unit (ICU) admission, to assess their course and response to initial treatment modality plasma exchange (PE) or intravenous immunoglobulins (IVIg) and their final outcome. children with severe GBS who had either actual or impending respiratory failure, bulbar involvement or rapid progression of acute flaccid paralysis with trunk, upper limb and neck involvement within 24 h of the onset of weakness were enrolled. 40 children were included. Following the initial treatment (33 subjects had 5 PE sessions each and IVIg in 7), 16 patients improved (40%), two died and 22 (55%) showed initial treatment failure. Axonal neuropathy, rapid progression and severe motor weakness significantly predicted poor response to therapy. At discharge, favorable outcomes (patient can walk unaided) were present in 22 cases (58%). Despite relatively low mortality, critically ill children with severe GBS have increased prevalence of axonal neuropathy and guarded response to initial therapy with PE or IVIg.

El-Anwar, N., M. El-Shabrawi, O. O. Shahin, R. Abdel Kareem, A. M. Salama, and sherif Baroudy, "Health-related quality of life and cognitive function in children with Crigler-Najjar syndrome type 1.", Paediatrics and international child health, vol. 44, issue 1, pp. 18-23, 2024. Abstract

BACKGROUND: The aim of the study was to assess the health-related quality of life (HRQOL) and cognitive function in patients with Crigler-Najjar syndrome (CNS) type I and its impact on their lives.

METHODS: Twenty-one patients diagnosed with CNS type I aged 1 month to 18 years in the Paediatric Hepatology Unit of Cairo University Children's Hospital were enrolled in this cross-sectional observational study. The patients' health-related quality of life (HRQOL) was assessed using the World Health Organization Quality Of Life BREF questionnaire (WHOQOL-BREF) and the Short Form 36 Health Survey Questionnaire (SF-36). Cognitive function was assessed using the Stanford-Binet Intelligence Scale: Fifth Edition (SB5).

RESULTS: All patients had a history of admission to a neonatal intensive care unit, 17 were managed by phototherapy only and 5 also underwent exchange transfusion. According to the WHOQOL questionnaire, 11 cases (52.4%) had a low QOL score, and 7 of 13 patients had an average score for their total IQ test. Cases with poor compliance to phototherapy had statistically significantly lower QOL scores (=0.001), while, according to the SF36 survey, cases who received exchange transfusion had statistically significantly higher cognitive function (=0.03). There was a positive correlation between the neurological effect as a complication of the disease and poor physical QOL.

CONCLUSION: Paediatric patients with CNS have significantly lower HRQOL, especially physically, psychologically and environmentally. It is recommended that assessment of HRQOL should be a routine part of follow-up in CNS patients. Patients whose HRQOL is affected receive regular psychiatric counselling, social support and rehabilitation. CNS: Crigler-Najjar syndrome; HRQOL: health-related quality of life; IQ: intelligence quotient; NICU: neonatal intensive care unit; QOL: quality of life; SB5: Stanford-Binet intelligence scale: 5th edition; SF-36: Short Form 36 Health Survey Questionnaire; UDGT: uridine diphosphate glucuronosyl transferase; UGT1A1: uridine 5'-diphosphate glucuronosyltransferase; WHOQOL-BREF: World Health Organization Quality of Life Brief Version.

N, E. - A., B. H, A. M. F, and R. Y, "Plasma exchange is the hope for critically ill children with life-threatening autoimmune hemolytic anemia", https://epag.springeropen.com/, vol. 72, 2024.
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