The Relationship of Circulating Proprotein Convertase Subtilisin/Kexin Type 9 With TSH and Lipid Profile in Newly Diagnosed Patients With Subclinical and Overt Hypothyroidism, noha adly sadik, Rashed Laila Ahmed, and El-Sawy Shereen Sadik , Clinical Medicine Insights: Endocrinology and Diabetes, Volume 15, p.1-9, (2022) pcsk9_published.pdf
Circulating miR-155 and JAK2/STAT3 Axis in Acute Ischemic Stroke Patients and Its Relation to Post-Ischemic Inflammation and Associated Ischemic Stroke Risk Factors, noha adly sadik, Rashed Laila Ahmed, and Mawla Mai Ahmed Abd-El , International Journal of General Medicine, Volume 14, p.1469-1489, (2021) mirna_155_pdf_1.pdf
Vitamin D receptor gene polymorphisms and 25(OH) vitamin D: Lack of association to glycemic control and metabolic parameters in type 2 diabetic Egyptian patients, Gendy, Hala Ibrahim El, noha adly sadik, Helmy Mona Youssry, and Rashed Laila Ahmed , Journal of Clinical & Translational Endocrinology, Volume 15, p.25-29, (2019)
Serum omentin-1 levels in type 2 diabetic obese women in relation to glycemic control, insulin resistance and metabolic parameters, nehal hamdy elsaid, noha adly sadik, Ahmed Nagwa Ramadan, Fayez Sherry Elisha, and Mohammed Nagwa Abd El-Ghaffar , Published in Journal of clinical & translational endocrinology , Volume 13, p.14-19, (2018) Abstract

Background
Omentin-1 a new anti-inflammatory adipokine has been identified as a major visceral (omental) secretory adipokine which plays important roles in glucose homeostasis, lipid metabolism, insulin resistance and diabetes. The aim of our study was to evaluate serum omentin-1 levels in type 2 diabetic obese females and assess its relation with glycemic control, insulin resistance and metabolic parameters.

Methods
The study included 60 obese type 2 diabetic females and 30 healthy female subjects formed the control group. They subjected to full clinical examination, weight, height, waist and hip circumference. Fasting (blood glucose, insulin, lipid profile, omentin-1) and HbA1c were measured. BMI and HOMA-IR were calculated. Our data analyzed and expressed in terms of mean ± SD. Pearson correlation performed to study the correlation of serum omentin-1 in relation to glycemic control, insulin resistance and metabolic parameters in the studied groups.

Results
We found significant decrease in serum omentin-1 levels in cases with mean ± SD (16.5 ± 2.6 pg/ml) compared to controls (25.3 ± 1.0 pg/ml) (P < 0.001). We also found strong significant negative correlations between serum omentin-1 and (BMI, fasting insulin, HOMA-IR) (r = -0.909, -0.853, -0.511) respectively (P < 0.001) and systolic blood pressure (r = -0.274, p = 0.031). The best cut off point of serum omentin-1 was 22.2 pg/ml to differentiate cases from controls using ROC curve analysis.

Conclusion
Our study has shown significant low levels of serum omentin-1 in obese type 2 diabetic females in comparison to healthy subjects. Omentin-1 inversely related to obesity, insulin resistance and SBP. No significant associations with glycemic control and fasting lipids. Serum omentin-1 can be used as a biomarker for obesity related metabolic disorders

The relationship between Matrix Metalloproteinase-10 (MMP-10) and atherosclerosis in Patients with chronic kidney disease, Belal, Dawlet, Deeb Manal El, Adly Noha, Mostafa Mohammed, Kaffas Khalid, and Mohammed Nahed , International Journal of Advanced Research (IJAR), (2014) Abstract

Background: Cardiovascular diseases (CVD) are the leading cause of death in patients with chronic kidney disease (CKD). Aim: As matrix metalloproteinases have a major role in atherosclerosis, we investigated the relationship between matrix metalloproteinase (MMP-10) and the severity of atherosclerosis in patients with chronic kidney disease. Methods: This study was evaluated in a cross-sectional study of 40 patients of CKD subdivided into 20 patients with different stages of kidney disease and 20patients on dialysis and 20 healthy controls. The severity of atherosclerosis was estimated with carotid intima media thickness (CIMT) by carotid ultrasound. Serum level of (MMP-10) was measured by ELISA. Results: MMP-10 level in the control group was ranging between 346 and 776 pg/dl with a mean of (601 + 132.12) and in the earlier stages of CKD group was ranging between 989 and 2569 pg/dl with a mean of (1857.45+ 387. 1). Also MMP-10 in patients on dialysis group (HDx) group was ranging between 1790 and 2986 pg/dl with a mean of (2306.45 + 335.247). The difference between all groups was statistically significant with P value <0.001. The carotid intima media thickness (CIMT) between all groups was statistically significant with P- value <0.001 between the HDx group and other groups and P value= 0.045 between the control and the CKD group. Also there was statistically significant positive correlation between MMP-10 and CIMT in all groups.