Said, M. F., W. Wadie, E. A. A. El-Haleim, R. E. A. Shiekh, and H. H. El-Zoheiry, "Probing new 3-hydrazinyl indole phenacetamide derivatives as multitarget anti-Alzheimer: Synthesis, in vivo, in vitro, and in silico studies", European Journal of Medicinal Chemistry, vol. 295, pp. 117720, 2025.
Saleh, N. S., N. N. E. El-Sayed, O. A. Saleh, H. A. Allam, N. M. Mohamed, S. E. - S. Abbas, and M. F. Said, "6,7-Dimethoxy-2-methyl-4-substituted quinazolines: Design, synthesis, EGFR inhibitory activity, in vitro cytotoxicity, and in silico studies", European Journal of Medicinal Chemistry, vol. 290, pp. 117502, 2025.
Rayan, S. A., M. F. Said, and R. F. George, "Insight on development of oxazole and imidazole derivatives as COX inhibitors with anti-inflammatory effects", Journal of Molecular Structure, vol. 1321, pp. 140148, 2025.
Gabr, B. S., A. R. Shalabi, M. F. Said, and R. F. George, "3,5-Disubstituted pyrazoline as a promising core for anticancer agents: mechanisms of action and therapeutic potentials", Future Medicinal Chemistry, vol. 17, issue 6, pp. 725-745, 2025.
Gabr, B. S., A. R. Shalabi, M. F. Said, M. S. Nafie, and R. F. George, Design and synthesis of novel 3,5-diphenyl pyrazolines acting as potent EGFR inhibitors with off-target antileukemic effect, , 2025.
Brown, L. V. D., A. S. Girgis, S. Patel, N. Samir, M. F. Said, A. T. Baidya, R. Kumar, J. Moore, A. Khadanga, R. Sakhuja, et al., "Novel isatin conjugates endowed with analgesic and anti-inflammatory properties: design, synthesis and biological evaluation", Future Medicinal Chemistry, vol. 18, issue 1, pp. 59–73, 2025.
Ahmed, R. F., W. R. Mahmoud, N. M. Abdelgawad, A. Belal, R. I. Alsantali, and M. F. Said, "Insight on novel sulfamoylphenyl pyrazole derivatives as anticancer carbonic anhydrase inhibitors", Molecular Diversity, vol. 29, pp. 4705–4725, 2024.
M. Adel Youssef, D. D. P., S. S. Panda, D. R. Aboshouk, M. F. Said, A. El Taweel, M. Gaballah, W. A. L. I. D. FAYAD, A. F. Soliman, A. Mostafa, N. G. Fawzy, et al., "Novel Curcumin Mimics: Design, Synthesis, Biological Properties and Computational Studies of Piperidone-Piperazine Conjugates", ChemistrySelect, vol. 7, issue 31, pp. e202201406, 2022.
Said, M. F., S. M. Marie, N. M. Mohamed, M. A. Mahrouse, and B. a Moussa, "Insight on novel oxindole conjugates adopting different anti-inflammatory investigations and quantitative evaluation.", Future medicinal chemistry, 2024. Abstract

A dual COX/5-LOX strategy was adopted to develop new oxindole derivatives with superior anti-inflammatory activity. Three series of oxindoles - esters -, - and imines - - were synthesized and evaluated for their anti-inflammatory and analgesic activities. Molecular docking and predicted pharmacokinetic parameters were done for the most active compounds. A new LC-MS/MS method was developed and validated for the quantification of in rat plasma. Compounds , , , and revealed % edema inhibition up to 100.00%; also, and showed 100.00% writhing protection. Compound showed dual inhibitory activity with IC = 0.0533 and 0.4195 μM for COX-2 and 5-LOX, respectively. Molecular docking rationalized the obtained biological activity. The pharmacokinetic parameters of from rat plasma were obtained.

Rayan, S. A., R. F. George, N. M. Mohamed, and M. F. Said, "Exploring of novel oxazolones and imidazolones as anti-inflammatory and analgesic candidates with cyclooxygenase inhibitory action.", Future medicinal chemistry, 2024. Abstract

Over the last few decades, therapeutic needs have led to a search for safer COX-2 inhibitors with potential anti-inflammatory and analgesic activity. A new series of oxazolone and imidazolone derivatives and were synthesized and evaluated as anti-inflammatory and analgesic agents. COX-1/COX-2 isozyme selectivity testing and molecular docking were performed. All compounds showed good activities comparable to those of the reference, celecoxib. The most active compounds , , , and showed promising gastric tolerability with an ulcer index lower than that of celecoxib. The molecular docking of -methoxyphenyl derivative showed alkyl interaction with the side pocket His75 of COX-2 and achieved the best anti-inflammatory activity, with a COX-2 selectivity index better than that of celecoxib.