Soliman, M., M. mohsen Soliman, A. El-Tawdy, and H. S. Shorbagy, "Efficacy of fractional carbon dioxide laser versus microneedling in the treatment of striae distensae", Journal of Cosmetic and Laser Therapy , 2018.
Dabbous, O. A., M. M. Soliman, N. H. Mohamed, M. Y. Elseify, M. S. Elsheikh, A. A. A. Alsharkawy, and M. M. Abd Al Aziz, "Evaluation of the improvement effect of laser acupuncture biostimulation in asthmatic children by exhaled inflammatory biomarker level of nitric oxide.", Lasers in medical science, vol. 32, issue 1, pp. 53-59, 2017 Jan. Abstract

Variable therapy of asthma is not sufficient yet to achieve good asthma control. Therapy decision requires serial investigations. Low-level laser acupuncture is a suitable non-invasive modality of complementary medicine. The exhaled breath condensate (EBC) is easy and useful to evaluate the efficacy of drugs or novel therapy. This study aimed to evaluate the effectiveness of low-level laser biostimulation of acupuncture points on asthma improvement in children. Forty-eight asthmatic children were subdivided into case (laser) group, which received 12 direct contact low-power laser acupuncture sessions (three sessions/week) on specific traditional Chinese acupuncture points for bronchial asthma, and control asthmatic group, which received sham laser acupuncture on the same acupoints and number of sessions of the case (laser) group. Low-power Multichannel Aculas-AM laser (grade II) of wave length 780 nm, output power 800 mw, and beam spot size 0.1 cm with continuous mode was used. Eighteen acupoints were stimulated for 2 min, giving energy of 9.6 J/cm/acupoint. The total session time was 3 min. Both groups were evaluated pre- and post-laser acupuncture intervention by recording levels of asthma control, pulmonary function, and EBC nitric oxide. In the case (laser) group, 91.7 % of patients experienced an improvement in the level of asthma control versus 25 % in the control group (p < 0.001). This was associated with a significant decrease of the breath condensate FENO concentration (p < 0.001) and significant increase of spirometry parameters (p < 0.001) in the case (laser) group. Application of laser acupuncture treatment given with conventional therapy can effectively improve bronchial asthma more than prescription of medications alone could.

Ramez, S. A., M. M. Soliman, M. Fadel, Faisal Nour El-Deen, M. Nasr, E. R. Youness, and D. M. Aboel-Fadl, "Novel methotrexate soft nanocarrier/fractional erbium YAG laser combination for clinical treatment of plaque psoriasis.", Artificial cells, nanomedicine, and biotechnology, pp. 1-7, 2018 Feb 15. Abstract

Psoriasis is a commonly encountered chronic dermatological disease, presenting with inflammatory symptoms in patients. Systemic treatment of psoriasis is associated with several adverse effects, therefore the development of a customized topical treatment modality for psoriasis would be an interesting alternative to systemic delivery. The therapeutic modality explored in this article was the comparative treatment of psoriatic patients using nanoparticulated methotrexate in the form of jojoba oil-based microemulsion with or without fractional erbium YAG laser. Assessment parameters included follow-up photography for up to 8 weeks of treatment, estimation of the psoriasis severity [TES (thickness, erythema, scales)] score, and histopathological skin evaluation. The prepared methotrexate microemulsion was clinically beneficial and safe in treatment of psoriasis vulgaris. The concomitant use of the fractional laser provided improvement in the psoriatic plaques within shorter time duration (3 weeks compared to 8 weeks of treatment), presenting an alternative topical treatment modality for psoriasis vulgaris.

Tawfik, A. A., I. Noaman, H. El-Elsayyad, N. El-Mashad, and M. Soliman, "A study of the treatment of cutaneous fungal infection in animal model using photoactivated composite of methylene blue and gold nanoparticle.", Photodiagnosis and photodynamic therapy, vol. 15, pp. 59-69, 2016 Sep. Abstract

BACKGROUND: Onychomycosis is a widespread public health problem, in which T. rubrum and T. mentagrophytes is the commenest causative organisms. Current medical therapy has many drawbacks and side effects. Methylene blue (m.b) photodynamic therapy (pdt) proved efficacy but with lengthy sessions.

OBJECTIVES: Optimizing methylene blue photodynamic therapy by combination of methylene blue photosensitizer and gold nanoparticles (aunps) in a composite as gold nanoparticles are efficient delivery systems and efficient enhancers of photosensitizers for antifungal photodynamic therapy.

MATERIALS AND METHODS: Eighty newzealand rabbit (Oryctolagus cuniculus) were used and categorized in eight equal groups as follows; healthy and infection control, composite photodynamic therapy and five comparative groups. Photodynamic therapy was initiated at day three to five post inoculation, for four sessions forty eight hours apart. Each group divided and light exposure at two fluencies; 80J and 100J. All groups were investigated macroscopically and microscopically (histopathology and scanning electron microscope) also flowcytometry assessment for cell death and X-ray analysis for gold nanoparticles accumulation in brain and liver tissues were determined.

RESULTS: Recovery from infection approaching 96% in gold nanoparticles+light group, around 40% in methylene blue photodynamic therapy and 34% in composite photodynamic therapy. The observed findings confirmed by apparent decrease of apoptosis, however small amounts of gold nanoparticles detected in brain and liver.

CONCLUSION: Light stimulated gold nanoparticles is a promising tool in treatment of onychomycosis.

Tawfik, A. A., I. Noaman, H. El-Elsayyad, N. El-Mashad, and M. Soliman, "A study of the treatment of cutaneous fungal infection in animal model using photoactivated composite of methylene blue and gold nanoparticle.", Photodiagnosis and photodynamic therapy, vol. 15, pp. 59-69, 2016 Sep. Abstract

BACKGROUND: Onychomycosis is a widespread public health problem, in which T. rubrum and T. mentagrophytes is the commenest causative organisms. Current medical therapy has many drawbacks and side effects. Methylene blue (m.b) photodynamic therapy (pdt) proved efficacy but with lengthy sessions.

OBJECTIVES: Optimizing methylene blue photodynamic therapy by combination of methylene blue photosensitizer and gold nanoparticles (aunps) in a composite as gold nanoparticles are efficient delivery systems and efficient enhancers of photosensitizers for antifungal photodynamic therapy.

MATERIALS AND METHODS: Eighty newzealand rabbit (Oryctolagus cuniculus) were used and categorized in eight equal groups as follows; healthy and infection control, composite photodynamic therapy and five comparative groups. Photodynamic therapy was initiated at day three to five post inoculation, for four sessions forty eight hours apart. Each group divided and light exposure at two fluencies; 80J and 100J. All groups were investigated macroscopically and microscopically (histopathology and scanning electron microscope) also flowcytometry assessment for cell death and X-ray analysis for gold nanoparticles accumulation in brain and liver tissues were determined.

RESULTS: Recovery from infection approaching 96% in gold nanoparticles+light group, around 40% in methylene blue photodynamic therapy and 34% in composite photodynamic therapy. The observed findings confirmed by apparent decrease of apoptosis, however small amounts of gold nanoparticles detected in brain and liver.

CONCLUSION: Light stimulated gold nanoparticles is a promising tool in treatment of onychomycosis.

Soliman, M., N. A. Samy, M. Abo Eittah, and M. Hegazy, "Comparative study between excimer light and topical antioxidant versus excimer light alone for treatment of vitiligo.", Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology, vol. 18, issue 1, pp. 7-11, 2016. Abstract

BACKGROUND: Vitiligo is an acquired idiopathic cutaneous disease characterized by pearly white patches of variable shapes and sizes. Various medical and surgical therapeutic options have been proposed to achieve repigmentation; phototherapy is one of the most efficient options. Topical therapies have been a mainstay of vitiligo treatment, with or without phototherapy.

AIM OF THE WORK: To compare the efficacy of combined topical antioxidant hydrogel and excimer light versus excimer light alone in treating vitiligo.

PATIENTS AND METHODS: Thirty patients were included in this comparative, prospective, randomized study. For each patient, at least 2-4 vitiliginous macules were randomly selected and treated while an untreated vitiliginous macule served as control. Lesions were divided into two groups: Group A received combination therapy of daily topical antioxidant plus excimer light, while Group B received only excimer light. Lesions were treated twice a week for a maximum of 24 sessions. Initial fluencies were adjusted individually according to the minimal erythema dose in vitiliginous skin. Efficacy based on repigmentation percentages were blindly evaluated by two independent physicians.

RESULTS: Group A lesions showed significant efficacy than group B (p < 0.001), specially on treating UV-sensitive lesions with no side effects.

CONCLUSION: Topical antioxidant and excimer light represents a valuable, effective therapy for localized vitiligo.

Soliman, M., H. ZAHER, N. E. Danasouri, A. Attia, and W. Tawfik, "Effect of pulsed dye laser on intercellular adhesion molecule-1 (ICAM-1) expression after treatment of psoriasis", Medical Laser Application, vol. 26, no. 1, pp. 20 - 26, 2011. AbstractWebsite

Background Intercellular adhesion molecule-1 (ICAM-1) is a member of the immunoglobulin super family of adhesion molecules that plays a role in transendothelial migration and adhesion processes involved in the pathogenesis of psoriasis. Previous studies have demonstrated partial and total clearance of psoriasis by selective photothermolysis of dermal vessels with the pulsed dye laser. Objective The aim of this study is to assess the efficacy of the pulsed dye laser (PDL) in treatment of chronic psoriatic plaque lesions by measuring changes in ICAM-1 expression in the epidermis and dermis of psoriatic patients before, during and after treatment, with correlation to the clinical improvement. Patients and methods Sixty patients with chronic plaque psoriasis were treated with flashlamp-pumped pulsed dye laser (FPDL) with 585 nm wavelength, 450 μs pulse duration, 7–8.5 J/cm2 fluence, and 7 mm spot size. Sessions were performed every 2 weeks with each patient receiving a total of 3 sessions. Clinical, histological, and immunohistochemical assessments were carried out. A correlation between plaque severity score (sum score) and changes in the mean of ICAM-1 expression was assessed throughout and after treatment. Results Reduction of ICAM-1 expression mean in psoriatic lesion was 1.83 ± 0.29 at week 2, 1.60 ± 0.19 at week 4, and 1.53 ± 0.18 at week 6 from the start of the laser treatment, compared to the baseline which was 2.90 ± 0.40. In the control group, ICAM-1 expression was 0.60 ± 0.07. A significant correlation between clinical improvement and reduction in ICAM-1 expression at weeks 4 and 6 of laser treatment was proven (p < 0.05). Conclusion ICAM-1 expression is reduced significantly after treatment of psoriasis with pulsed dye laser, which can be used as an indicator for its efficacy.

Soliman, M., A. E. Kharbotly, and A. Saafan, "Management of oral lichen planus using diode laser (980nm). A clinical study", Egyptian Dermatology Online Journal, vol. 1, pp. 1-3, 2005. Abstractpaper.pdf

The present study was conducted on 25 patients suffering
from persistent oral lichen planus (OLP). The cases were selected
from the out patient clinic of the National Institute of Laser-
Enhanced Sciences, Cairo University. OLP was diagnosed
clinically and histologically. Patients were advised to stop any
medications for treatment of OLP three months before laser
treatment. Patients were treated by diode laser (980 nm) at the
affected areas of oral mucous membrane with defocused mode
until blanching of the treated area. Patients were followed up three
days, one, two and four weeks after treatment to assess healing
process and any postoperative complications. Patients were
examined after six months for recurrence. No serious
complications were recorded, apart from slight edema and pain.
Complete healing occurred after the second week. After six months
follow up, recurrence occurred only in three patients (12%). Diode
laser (980nm) provides a marked clinical improvement without the
need for neither local nor systemic treatment.

Soliman, M., A. E. Kharbotly, and A. Saafan, "Management of oral lichen planus using diode laser (980nm). A clinical study", Egyptian Dermatology Online Journal, vol. 1, pp. 1-3, 2005. Abstractpaper.pdf

The present study was conducted on 25 patients suffering
from persistent oral lichen planus (OLP). The cases were selected
from the out patient clinic of the National Institute of Laser-
Enhanced Sciences, Cairo University. OLP was diagnosed
clinically and histologically. Patients were advised to stop any
medications for treatment of OLP three months before laser
treatment. Patients were treated by diode laser (980 nm) at the
affected areas of oral mucous membrane with defocused mode
until blanching of the treated area. Patients were followed up three
days, one, two and four weeks after treatment to assess healing
process and any postoperative complications. Patients were
examined after six months for recurrence. No serious
complications were recorded, apart from slight edema and pain.
Complete healing occurred after the second week. After six months
follow up, recurrence occurred only in three patients (12%). Diode
laser (980nm) provides a marked clinical improvement without the
need for neither local nor systemic treatment.