Hemeda, A., and A. Fathy, Cardio-metabolic problem in Egypt, , 2020. cardiometabolic_.pdf
Naga, M., M. Amin, D. Elgendi, A. Elbadri, M. Fawzi, A. Foda, S. Esmat, D. S. Abdel-Fattah, S. Gabl, M. Kamal, et al., "Low-density lipoprotein receptor genetic polymorphism in chronic hepatitis C virus Egyptian patients affects treatment response", World J Gastroenterol , vol. 21, issue 39, pp. 10931-11204, 2015. wjg-21-11141.pdf
Amin, M. A., A. Ali, M. Kassem, N. Al-Garem, and S. Farid, "Clinical Study on the Therapeutic Role of Midodrine in Non azotemic Cirrhotic Patients with Tense Ascites: A Double-Blind, Placebo-Controlled, Randomized Trial ", hepato-gastroenterology, vol. 61, issue clinical practice , pp. 1915-1924, 2014. midodrine_paper.pdf
Fouad, A., D. Sabry, R. Ahmed, M. Kamal, S. A. Allah, S. Marzouk, M. Amin, R. Abd El Aziz, A. El Badri, H. Khattab, et al., "Comparative diagnostic study of biomarkers using FibroMax™ and pathology for prediction of liver steatosis in patients with chronic hepatitis C virus infection: an Egyptian study.", International journal of general medicine, vol. 6, pp. 127-34, 2013. Abstract

BACKGROUND: Steatosis is common in patients with hepatitis C virus (HCV) infection and may be a major determinant of progression of liver injury. This study evaluated FibroMax™ for noninvasive diagnosis of steatosis in patients with chronic HCV.

METHODS: This cross-sectional study included 44 patients naïve to treatment who were referred to our hepatology clinic for assessment of fitness for antiviral therapy. Chronic HCV infection was diagnosed by viral markers. Investigations included assessment of abdominal ultrasonography, liver biopsy, calculation of body mass index, and biomarker parameters in serum using FibroMax.

RESULTS: Histopathology of liver biopsies showed steatosis in 30 of 44 (68%) patients. FibroMax results were positively correlated with viral load by quantitative polymerase chain reaction and histopathological findings. Body mass index was significantly higher in steatotic patients (P = 0.003) and was significantly associated with the results on FibroMax (P = 0.005).

CONCLUSION: FibroMax was correlated with histopathology and body mass index in patients with HCV. Abdominal ultrasonography could not be used as a single tool to diagnose steatosis with HCV. Steatosis is correlated with viral load, which suggests a direct viral effect. We recommend FibroMax assessment in a larger number of patients to assess its applicability in patients with HCV and steatosis.

Abdel Aziz, M. T., D. El-Miligy, M. A. Amin, A. El Ansari, H. H. Ahmed, S. Marzouk, and D. Sabry, "Molecular evaluation of apoptotic versus antiapoptotic angiogenic markers in hepatocellular carcinoma.", Clinical biochemistry, vol. 41, issue 12, pp. 1008-14, 2008 Aug. Abstract

OBJECTIVE: To assess the role of HO-1 in HCC progression and to study the expression of apoptotic factors represented by TNF-alpha, and Fas-L versus antiapoptotic and angiogenic factors represented by HO-1, TGF-beta, HGF, and VEGF in HCC compared to non cancerous cirrhotic liver.

DESIGN AND METHODS: Liver biopsies were taken from twelve patients with grade II HCC confined to the liver and twelve patients with non cancerous liver cirrhosis (served as control). RT-PCR of previous genes was evaluated.

RESULTS: HO-1, VEGF, HGF, and TNF-alpha genes were significantly increased (P<0.05) in HCC compared to control. Fas-L showed a significant decrease (P<0.05) in HCC compared to control. TGF-beta was higher in HCC than control but the difference was not statistically significant (P>0.05). HGF showed significant positive correlation with HO-1 (r=0.8217, P=0.001).

CONCLUSION: HCC is associated with increased expression of VEGF, HGF, and TGF-beta, and with suppression of Fas-L. In addition, HO-1 is highly significantly expressed in HCC. The significant positive correlation between HO-1 and HGF was first reported in Egyptian human liver biopsies, and this suggests that it may play a role in the progression of hepatocellular carcinoma.

Amin, M. A., D. Sabry, L. A. Rashed, W. M. Aref, M. A. el-Ghobary, M. S. Farhan, H. A. Fouad, and Y. A. - A. Youssef, "Short-term evaluation of autologous transplantation of bone marrow-derived mesenchymal stem cells in patients with cirrhosis: Egyptian study.", Clinical transplantation, vol. 27, issue 4, pp. 607-12, 2013 Jul-Aug. Abstract

BACKGROUND: Stem cell-based therapy has received attention as a possible alternative to organ transplantation. The aim of this study was to assess the safety and efficacy of autologous transplantation of bone marrow (BM)-derived stromal cells in post-HCV liver cirrhosis patients.

METHODOLOGY: 10 × 10(6) of isolated human bone marrow (HBM)-stromal cells in 10 mL normal saline were injected in the spleen of 20 patients with end-stage liver cirrhosis guided by the ultrasonography, and then patients were followed up on monthly basis for six months.

RESULTS: A statistically significant decrease was detected in the total bilirubin, aspartate transaminase (AST), alanine transaminase (ALT) (p-value<0.01), prothrombin time (PT), and international normalized ratio (INR) levels (p-value<0.05), while a statistically significant increase in the albumin and PC (p-value<0.05) after follow-up.

CONCLUSION: This study suggested the safety, feasibility, and efficacy of the intrasplenic injection of autologous BM stromal cells in improving liver function in Egyptian patients with cirrhosis.

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