Elhamid, Y. A. A., G. S. Elazkalany, M. H. Niazy, and A. Y. Afifi, "Anxiety and depression in primary knee osteoarthritis patients: are they related to clinical features and radiographic changes?", Reumatologia, vol. 62, issue 6, pp. 421-426, 24-12-2025, 2024.
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Niazy, M. H., G. N. Fakhry, and S. M. Fawzy, "Clinical significance of peripheral nervous system involvement in systemic lupus erythematosus patients: Relation to disease activity and damage index", The Egyptian Rheumatologist, vol. 45, pp. 171-181, 2023.
Shahin, A. A., E. Khallaf, L. A. Salaheldin, S. A. M. Soliman, Y. S. Rezk, and M. H. Niazy, "Idiopathic granulomatous mastitis in seventy seven-female patients: Management, follow up of an overlooked immune-mediated disease, and review of literature", The Egyptian Rheumatologist, vol. 45, pp. 183-189, 2023.
Gamal, S. M., A. Mokbel, M. H. Niazy, F. T. Elgengehy, N. Y. Elsaid, N. A. Fouad, N. Sobhy, M. Tantawy, S. S. Mohamed, R. M. Ghaleb, et al., "Comorbidities among Egyptian systemic lupus erythematosus: The COMOSLE-EGYPT study.", Chronic illness, vol. 19, issue 4, pp. 791-803, 2023. Abstract

OBJECTIVE: To study the prevalence and impact of comorbidities among a cohort of patients with systemic lupus erythematosus (SLE).

METHODS: This study is retrospective, multicenter including 902 Egyptian patients with SLE. Medical records were reviewed for demographic data, clinical characteristics, routine laboratory findings, immunological profile, and medications. Moreover, SLE Disease Activity Index (SLEDAI), and the Systemic Lupus International Collaborating Clinics/American College Rheumatology Damage Index scores were calculated.

RESULTS: Comorbidities were found in 75.5% of the studied group with hypertension and dyslipidemia as the most frequent comorbidities (43.1% and 40.1%, respectively), followed by sicca features, avascular necrosis, diabetes, osteoporosis and renal failure (11.5%,9%, 9%,8.9%, and 7.1%, respectively). Multivariate regression model showed statistically significant relation between the presence of comorbid condition and each of age ( = 0.006), disease duration ( = 0.041), SLEDAI at onset ( < 0.001), cyclophosphamide intake ( = 0.001), and cumulative pulse intravenous methylprednisone ( < 0.001). Also, when adjusted to age and sex, those with multiple comorbid conditions had 18.5 increased odds of mortality compared to those without comorbidities (odds ratio (OR), 95% confidence interval (CI) = 18.5 (6.65-51.69)].

CONCLUSION: Patients with SLE suffer from several comorbidities, with an increasing risk with age, longer disease duration, higher SLEDAI at onset, cyclophosphamide intake and cumulative pulse intravenous methylprednisone. Risk of mortality is exponentiated with multiple comorbidities.

El-Shazly, R., M. H. Niazy, N. M. Riad, F. H. Abdelraouf, and R. M. ElRefai, "Krebs von den Lungen-6 (KL-6), soluble programmed cell death-1 (sPD-1) and its ligand-1(sPDL-1) in systemic sclerosis patients: Relation to disease parameters", The Egyptian Rheumatologist, vol. 44, pp. 333–337, 2022. kl6_pd1_ppdl1_2022.pdf
Sobhy, N., M. H. Niazy, and I. Siam, "Secondary amenorrhea in a cohort of Egyptian systemic lupus erythematosus patients", Egyptian Rheumatologist, vol. 42, issue 3, pp. 27-30, 2020.
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Sobhy, N., M. H. Niazy, and A. Kamal, "Lymphopenia in systemic lupus erythematosus patients: Is it more than a laboratory finding?", Egyptian Rheumatologist, vol. 42, issue 1, pp. 23-26, 2020.
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Gamal, S. M., S. S. Mohamed, M. Tantawy, I. Siam, A. Soliman, and M. H. Niazy, "Lupus-related vasculitis in a cohort of systemic lupus erythematosus patients", Archives of Rheumatology, vol. 36, issue 4, pp. 595-602, 2021.
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Niazy, M. H., W. Gaber, S. Sayed, O. G. Shaker, and T. A. Gheita, "The anti-aging protein alpha- Klotho in systemic sclerosis patients: does a relationship to telangiectasia exist?", Zeitschrift für Rheumatologie volume , vol. 79, pp. 404-409, 2020.
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