For Diploma Students

For Diploma Students enrolled in the First semester of the academic year 2016/2017

We will meet together in the following lectures:

Lecture (1): Sunday, 15/01/2017, at 11:00 AM entitled "Clinical Pathology of Pancreas and Pancreatic Disorders: Exocrine Pancreas".

Lecture (2): Sunday, 22/01/2017, at 11:00 AM entitled "Clinical Pathology of Pancreas and Pancreatic Disorders: Endocrine Pancreas".

Ibrahim, A. K., A. M. ElBehairy, K. M. A. Mahran, and W. S. Awad, "Clinical and laboratory diagnosis of piroplasmids in naturally infected cattle in Egypt", J.Egypt.vet.med.Assoc., vol. 69, no. 2, pp. 191–203, 2009. AbstractFull-text

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El-Shamy, E., A. El-Sissi, K. M. A. Mahran, A. R. Ahmed, and S. Y. Ahmed, "Clinico-immunological Studies on the Toxicity of Acrylamide and its Chemoprevention by Lipoic Acid in Rats", Egyptian Journal of Comparative Pathology and Clinical Pathology, vol. 29, issue 1, pp. 75-89, 2016. AbstractFull-text

The present study was aimed to investigate the hazardous effects of acrylamide (ACR) in rats and the efficacy of the lipoic acid (LA) to overcome these effects. For this purpose, 140 rats were randomly assigned to four groups: group 1 (G1): Control group; Group2 (G2) and Group3 (G3): Rats were intoxicated with ACR, 5.0 mg /kg b.wt/ day, in drinking water for 3 months . Beside (ACR) rats in (G3) were co-treated with LA, 100 mg/kg b.wt., in drinking water. Group4 (G4): Rats were given LA in the same dose. Acrylamide intoxicated rats revealed neurobehavioral symptom, anemia, significant increase in hepatic enzymes, alterations in renal function, glucose and hypoproteinemia. Also there were significant inhibition in the activities of creatine kinase (CK) and cholinesterase (ChE). Moreover, ACR induce oxidative stress manifested by significant increase in malondialdehyde (MDA) and nitric oxide (NO) and depletion of glutathione (GSH). The inhibition of innate immunity was manifested by significant decrease of phagocytic activity and index of peritoneal macrophage (PM), and significant increase in lysozyme activity. The genotoxicity of ACR were demonstrated by comet assay, chromosomal aberrations and micronucleus test. Co-administration of LA with ACR significantly ameliorated hazardous changes of ACR comparing to ACR intoxicated group. Also lipoic acid induces slight protection against ACR genotoxicity. Therefore, LA seems to be a good candidate for therapeutic intervention against ACR toxicity and could be contributed into clinical application.

Kelany, W. M., S. A. Sherein, K. M. A. Mahran, M. A. Dardery, and others, "Studies On Feline Hepatic Lipidosis", Proceedings of the 4th Scientific Conference of Animal Wealth Research in the Middle East and North Africa, Foreign Agricultural Relations (FAR), Egypt, 3-5 October 2011.: Massive Conferences and Trade Fairs, pp. 232–247, 2011. AbstractFull-text

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Awad, W. S., A. K. Ibrahim, K. Mahran, K. M. Fararh, and M. A. I. Moniem, "Evaluation of different diagnostic methods for diagnosis of Lumpy skin disease in cows", Tropical animal health and production, vol. 42, no. 4: Springer, pp. 777–783, 2010. AbstractFull-text

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Nassar, S. A., A. H. Mohamed, H. Soufy, S. M. Nasr, and K. M. Mahran, "Immunostimulant effect of Egyptian propolis in rabbits", The Scientific World Journal, vol. 2012: Hindawi Publishing Corporation, 2012. AbstractFull-text

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Mahran, K. M. A., "Clinicopathological Studies on Endosulfan-Induced Oxidative Stress and the Protective Role of Vitamin E", Global Veterinaria, vol. 11, no. 2, pp. 258–265, 2013. AbstractFull-text

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Veterinary Clinical Pathology (CLP 454)

Clinical pathology is concerned with the diagnosis of disease based on the laboratory analysis of bodily fluids such as blood, urine or cavitary effusions, or tissue aspirates using the tools of chemistry, microbiology, hematology and molecular pathology.

For level (4) undergraduate students, Faculty of Veterinary Medicine, Cairo University.

Youssef, S. Y., S. Yasien, W. M. A. Mousa, S. M. Nasr, E. A. M. El-Kelesh, K. M. Mahran, and A. H. Abd-El-Rahman, "Vector identification and clinical, hematological, biochemical, and parasitological characteristics of camel (Camelus dromedarius) theileriosis in Egypt.", Tropical animal health and production, vol. 47, issue 4, pp. 649-56, 2015 Apr. AbstractFull-text

The objectives of the present study were to identify a possible tick vector and to determine the prevalence of camel theileriosis in Egypt using blood smears stained with Giemsa's stain and PCR assay. Hemogram and serum biochemical constituents were also investigated. A total of 243 camels, aged 3-5 years, were examined. The results revealed that 75 (30.86 %) camels were infected with Theileria spp. of Giemsa-stained blood smears. Hyalomma dromedarii was identified as the carrier tick of Theileria spp. Multinucleated sporoblast and free sporozoite were observed in the salivary gland smears from collecting ticks. PCR result revealed that Theileria annulata was the most abundant in camels (60 %) followed by Theileria spp. (10 %). Macrocytic hypochromic anemia was recorded in the infected camels with T. annulata. Leukocytosis, neutrophilia, eosinophilia, and lymphopenia were also observed in the infected group. In the serum of infected camels, total proteins, albumin, β-globulin, and A/G ratio were significantly decreased (P < 0.05); however, total globulins and α- and γ-globulins were markedly increased (P < 0.05). The activity of aspartate aminotransferase and the levels of glucose, creatinine, and high-density lipoprotein cholesterol were markedly increased (P < 0.05) in the infected group. In contrast, triglycerides and total cholesterol concentrations were significant decreased (P < 0.001) in the infected group. In conclusion, a high prevalence of camel theileriosis was recorded in apparently healthy camels. H. dromedarii commonly infested these camels and were found infected with the transmissible forms of Theileria, indicating a role in transmission. Camels infected with T. annulata induced alterations in the cellular and biochemical constituents.

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