PhD research work included:
- Improving the poor oral bioavailability of avanafil using different techniques, these included:
- Different combinations of nanocrystallization technologies (anti-solvent precipitation, ultrasonication and high pressure homogenization). Effects of different non-ionic stabilizers and cryoprectants were investigated.
- Addition of different hydrophilic polymers in different concentrations to avanafil-cyclodextrin inclusion complexes using solvent evaporation in rotavap and kneading techniques. These included (cellulose derivatives, polyethylene glycol, polyvinyl pyrrolidone, chitosan).
- Formulation of solid self-nanoemulsifying drug delivery systems using different surfactant/co-surfactant/oil combinations.
- Solid state characterization (Infrared spectroscopy; Differential scanning calorimetry; X-ray diffraction; Scanning electron microscopy).
- Particle size analysis (Dynamic light scattering; Transmission electron microscopy).
- In vitro dissolution study and bioequivalence study on rabbits.
- Stability study at accelerated storage conditions.
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