Improving the poor oral bioavailability of avanafil using different techniques, these included:
Different combinations of nanocrystallization technologies (anti-solvent precipitation, ultrasonication and high pressure homogenization). Effects of different non-ionic stabilizers and cryoprectants were investigated.
Addition of different hydrophilic polymers in different concentrations to avanafil-cyclodextrin inclusion complexes using solvent evaporation in rotavap and kneading techniques.
