Background: studies on sperm maturation, epididymal histology, or epididymal tubule physiology are significant parts in reproductive researches.
Aim: The present study was aimed to evaluate the effect of induced hypercholesterolemia on the epididymis of adult albino rats and to clarify the possible protective role of selenium.
Material and Methods: Forty adult albino Wistar rats were divided into four groups; untreated control group (I), sham control (group II), group III (induced hypercholesterolemia), group IV (induced hypercholesterolemia treated with selenium 0.25 mg/kg/day).
Results: Histological and ultrastructural examination of the epididymal epithelial cells of hypercholesterolemic rats (group III) showed loss of cilia with many vaculations, fatty degenerative changes and increased collagen fibers. Morphometrically significant increase (p<0.0001) in the area percent of collagen fibers with no significant change in the optical density of PAS reaction (p˃0.05). Selenium treated group (group IV) produced marked improvement in histological, ultrastructural and morphometric results as compared with group III.
Conclusion: It could be concluded that hypercholesterolemia produced deleterious effects to the epididymis and selenium could attenuate these effects.