Shafik, R. E., N. M. Hassan, Y. E. M. Meligui, and H. E. Shafik, "The Meningioma 1 (MN1) Gene is an Independent Poor Prognostic Factor in Adult Egyptian Acute Myeloid Leukemia Patients", Meningioma 1Gene an Independent Poor Prognostic Factor in Adult AML Patients, vol. 18, issue 3, pp. 609-613, 2017. Abstract

To determine the prognostic importance of meningioma 1 (MN1) gene expression levels in the context of
other predictive markers for acute myeloid leukemia (AML) cases. Methods: MN1 expression was measured in 85
newly diagnosed adults younger than 60 years by real-time reverse-transcriptase polymerase chain reaction. Results: At
diagnosis 67.4% of cases had elevated MN1 expression, this being associated with a worse prognosis, higher incidence
of lymphadenopathy and CD34 transcript expression (p=0.02 and <0.001, respectively). No other molecular or clinical
characteristics were significantly associated with MN1expression. Patients with high MN1 expression had lower
complete response rate at day 15 compared to patients with low MN1 expression (p=0.09) and a significantly higher
relapse rate (21.1% versus 7.7%, respectively, p=0.04). Patients with high MN1 expression had shorter TTP compared
to those with low expression, p= 0.07. Conclusion: MN1 expression may predict outcome in AML patients. The MN1
gene and micro RNA expression suggest a biological feature that could be used as therapeutic targets.

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