Rostom, Y., O. G. Hussein, A. M. Mahmoud, M. A. Kawy, M. R. Rezk, and D. A. Ahmed, "Novel Carbon Nanotubes/Gold Nanoparticles Modified Carbon Paste Electrochemical Sensor for Antazoline Determination in Aqueous Humor", Journal of The Electrochemical Society, vol. 171, pp. 037510, 2024.
Rostom, Y., M. R. Rezk, M. Wadie, E. M. Abdel-Moety, and H. M. Marzouk, "State-of-the-art mathematically induced filtration approaches for smart spectrophotometric assessment of silodosin and solifenacin mixture in their new challenging formulation: Multi-tool greenness and whiteness evaluation", Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, vol. 307: Elsevier, pp. 123650, 2024. Abstract
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Lotfy, H. M., S. S. Saleh, Y. Rostom, R. H. Obaydo, and D. A. Ahmed, "Advanced approaches in green univariate spectrophotometric methods", Sustainable Approaches in Pharmaceutical Sciences: John Wiley & Sons, Ltd Chichester, UK, pp. 157-215, 2023. Abstract
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Hussein, O. G., D. A. Ahmed, M. R. Rezk, M. A. Kawy, and Y. Rostom, "Exquisite integration of quality-by-design and green analytical approaches for simultaneous determination of xylometazoline and antazoline in eye drops and rabbit aqueous humor, application to stability study", Journal of Pharmaceutical and Biomedical Analysis, vol. 235: Elsevier, pp. 115598, 2023. Abstract
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Hussein, O. G., Y. Rostom, M. A. Kawy, M. R. Rezk, and D. A. Ahmed, "Spectrophotometric platform windows' exploitation for the green determination of Alcaftadine in presence of its oxidative degradation product", Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, vol. 297: Elsevier, pp. 122737, 2023. Abstract
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Sami, I., Y. Rostom, H. H. Monir, and Y. S. El-Saharty, "Sustainable spectrophotometric resolution techniques for a spectrally overlapping mixture of Articaine Hydrochloride and Epinephrine Bitartrate with challenging formulation ratio", Sustainable Chemistry and Pharmacy, vol. 32: Elsevier, pp. 100994, 2023. Abstract
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Hussein, O. G., D. A. Ahmed, M. A. Kawy, M. R. Rezk, and Y. Rostom, "A novel green spectrofluorimetric method for simultaneous determination of antazoline and tetryzoline in their ophthalmic formulation.", Luminescence : the journal of biological and chemical luminescence, vol. 39, issue 3, pp. e4728, 2024. Abstract

A novel spectrofluorimetric method has been developed for determination of antazoline (ANT) and tetryzoline (TET) in their pharmaceutical formulation. A combined application of synchronous spectrofluorimetry and second derivative mathematical treatment was developed. The proposed method depends on reacting the cited drugs with dansyl chloride (DNS-Cl) being a suitable derivatizing agent generating highly fluorescent derivatives measured at emission wavelengths of 703.0 and 642.0 nm after excitation wavelengths of 350.0 and 320.0 nm for ANT and TET, respectively. The joint use of synchronous spectrofluorimetry with second derivative mathematical treatment is for the first time to be developed and optimized in aid of using fluorescence data manager software generating second derivative peak amplitudes at 556.5 nm for ANT and 516.7 nm for TET. Linear responses have been represented over a wide range of concentration (0.5-12.0 μg/mL for ANT and 0.5-10.0 μg/mL for TET). Additionally, statistical comparison of the developed method with the official ones has been carried out where no significant difference was found. Additionally, greenness profile assessment was accomplished by means of four metric tools. Indeed, the method developed is found to be precise, sensitive, and discriminating to assess the cited drugs for regular analysis.

Soliman, R. M., M. A. Tantawy, N. M. Mostafa, Y. M. Fayez, H. H. Monir, and Y. Rostom, "Smart Chemometric-Assisted Spectrophotometric Approaches for Simultaneous Quantification of Tertiary Combination Recommended for COVID-19 Supportive Treatments With Their Greenness Assessment.", Journal of AOAC International, vol. 107, issue 5, pp. 774-784, 2024. Abstract

BACKGROUND: There is an increasing interest of the scientific community in developing innovative methodologies for their analysis needs within a green analytical chemistry framework. UV spectrophotometry is one of the most promising eco-friendly methods, which is integrated with advanced chemometric tools to enhance the selectivity of the analysis of complex mixtures with severe overlapped signals.

OBJECTIVE: Simultaneous determination of a triple-combination of pseudoephedrine hydrochloride (PSE), carbinoxamine maleate (CRX), and paracetamol (PAR) using an artificial intelligence system and multivariate calibration methods. This combination has been recently recommended for COVID-19 home-treated patients as part of a symptomatic treatment.

METHODS: Namely, the suggested models are artificial neural networks, partial least-squares, and principal component regression. The proposed algorithms were optimized and developed with the aid of a five-level, three-factor experimental design.

RESULTS: The investigated methods were applied over the concentration range of 100-180 μg/mL, 18-16 μg/mL, and 4-12 μg/mL for PSE, CRX, and PAR, respectively. The models' validation results demonstrated excellent recoveries (around 98 to 102%), signaling the approaches' outstanding resolution capacity for the cited compounds in the presence of common excipients. The outcomes of the studied methods were statistically compared to the official approaches, and no significant difference was found.

CONCLUSIONS: The suggested models were efficiently employed to determine the selected drugs in their combined tablets without any initial separation steps. The impact of these methods on the environment was evaluated via greenness tools: namely, the National Environmental Method Index, Raynie and Driver's green assessment method, Analytical Eco-Scale, Green Analytical Procedure Index, and Analytical Greenness Metric.

HIGHLIGHTS: Green chemometric quality assessment of PSE, CRX, and PAR in their pure and pharmaceutical dosage forms. The established approaches are innovative, sustainable, smart, fast, selective, and cost-effective. These models are potential green nominees for routine analysis of the investigated mixture in quality control laboratories.

Hussein, O. G., Y. Rostom, M. A. Kawy, M. R. Rezk, and D. A. Ahmed, "Green TLC-Densitometric Method for Simultaneous Determination of Antazoline and Tetryzoline: Application to Pharmaceutical Formulation and Rabbit Aqueous Humor.", Journal of chromatographic science, vol. 62, issue 9, pp. 807-814, 2024. Abstract

Ophthalmic pharmaceutical preparation containing antazoline (ANT) and tetryzoline (TET) is prescribed widely as an over the counter medication for allergic conjunctivitis treatment. Development of a selective, simple and environmentally friendly thin-layer chromatographic method established to determine both ANT and TET in their pure forms, pharmaceutical formulation and spiked aqueous humor samples. By using silica gel plates and means of a developing system consists of ethyl acetate:ethanol (5:5, by volume), the studied drugs separation was achieved, and scanning was carried out at 220.0 nm for the separated bands with a 0.2-18.0 μg/band concentration range for each of ANT and TET. Standard addition technique application was carried out to determine the proposed method validity. Statistical comparison was made between the proposed method and the official methods ANT and TET showing no significant difference concerning accuracy and precision. Furthermore, greenness profile assessment was accomplished by means of four metric tools, namely, analytical greenness, green analytical procedure index, analytical eco-scale and national environmental method index. Highlights.

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