, Research Journal of Pharmaceutical, Biological and Chemical Sciences, Volume 7, Issue 7, p.647-655, (2015)
The aim of the present study is to investigate the protective effect of zinc (6.13 mg /kg bw), selenium
(0.4 mg /kg bw), vitamin C (100mg /kg bw), vitamin E (40 mg /kg bw) and epicatechine (4.5 mg /kg bw) on
cadmium – exposed rats (1.23 mg /kg bw), 5 times per week for 30 days. Zn+2 significantly decreased the
elevated level of urea in serum, but creatinine has still been at a higher level. Serum renal markers, β2
microglobulin (β2 MG) concentration and the activities of N-acetyl –β-D glucosaminidase (NAG) and alanine
aminopeptidase (AAP) were significantly decreased by cadmium and did not return to the normal level when
using the antioxidants.While epicatechine increased the NAG activity again. Bone resorption marker, Ctelopeptide
of collagen-alpha-(1) chain (CTX-1) was increased by Cd and declined again by Zn+2 and all
antioxidants except Se. The oxidative stress biomarkers, serum glutathione peroxidase (GPx) activity was
decreased by cadmium and improved by all protective factors in the present study, while the elevated level of
malonaldehyde (MDA) was ameliorated by Zn only. The protective factors, except vitamin C, decreased the
elevated level of AST, in cadmium-induced toxicity. In addition, Se, vitamins C and E improved the lowered
level of albumin. The used protective antioxidants improved the elevated levels of cholesterol, LDL-C and
triglycerides in serum occurred by cadmium toxicity. Our results suggest that Zn+2 and some antioxidants may
protect against cadmium-induced toxicity.
