Nano selenium protects against deltamethrin-induced reproductive toxicity in male rats, Hozyen, Heba F., Khalil Heba M. A., Ghandour Rehab A., Al-Mokaddem Asmaa K., Samer M., and Azouz Rehab A. , Toxicology and Applied Pharmacology, Volume 408, (2020)
Coadministration of Ginger Roots Extract and Vitamin E Improves Male Fertility of Streptozotocin-Induced Diabetic Rats , and Mostafa Abbas Shalaby1*, Rehab Ali Ghandour2 Shimaa Ramadan Emam1 , International Journal of Veterinary Science , (2021) Abstract

Ginger is an important medicinal plant in folk medicine. Antioxidant, antidiabetic, and anti-inflammatory effects have been reported in ginger extracts. This study was performed to examine how ginger extract (GE) and vitamin E (Vit E) have affected the fertility in Streptozotocin-induced diabetic male rats. Sixty adult male rats were randomly assigned into six groups (n=10 rats). Group 1 served as a negative control, while the other animals were intraperitoneally injected with Streptozotocin (50mg/kg) after fasting for 16 hours to induce diabetes. Group 2 was kept as a diabetic positive control. While groups 3 and 4 were orally given GE alone at 300 and 600mg/kg for 65 consecutive days to cover the whole spermatogenic cycle in rats, respectively. For the same period, groups 5 and 6 received GE (300 and 600mg/kg) plus Vit E (200mg/kg). Serum samples were obtained to estimate blood glucose, insulin, testosterone, FSH, and LH levels. Sex organs have been weighed, besides semen picture and histopathology of the testis were carried out. The results revealed that co-administration of GE and Vit. E increased the fertility index, weights of the testis and epididymis, serum testosterone level and improved semen quality in Streptozotocin-induced diabetic rats. Moreover, co-administration of GE and Vit. E caused hypoglycemia and hypoinsulinemia in administered rats compared to the diabetic positive control. Mild to moderate testicular degeneration and incomplete arrest of spermatogenesis were seen by histopathological examination of diabetic control group. Moreover, GE and Vit. E alleviated testicular lesions induced by diabetes, and improved spermatogenesis in treated groups. Conclusively, diabetic patients who are sexually impotent may benefit from a dietary supplement containing ginger roots and vitamin E.

Oxidative stress in spp. infected donkeys treated with piperazine citrate versus doramectin., Elmeligy, Enas, Abdelbaset Abdelbaset, Elsayed Hanan K., Bayomi Sara A., Hafez Ahmed, Abu-Seida Ashraf M., El-Khabaz Khaled A. S., Hassan Dalia, Ghandour Rehab A., and Khalphallah Arafat , Open veterinary journal, Volume 11, Issue 2, p.238-250, (2021) Abstract

Background: Parasitic infection is one of the main problems in equidae, particularly donkeys.

Aim: This study evaluated the oxidative stress in donkeys infected with spp by determining the correlation between antioxidants levels; malondialdehyde (MDA), total antioxidant capacity (TAC), and the severity of parasitic infection. It also compared the therapeutic efficacy of piperazine citrate as an oral anthelmintic drug and Doramectin as an injectable one.

Methods: The study was conducted on 40 donkeys naturally infected with spp. These donkeys were divided into two groups (20 donkeys each) according to treatment; One group was treated with piperazine citrate (PTG) and the other with doramectin (DTG). Thorough clinical examination, hematological, biochemical, and parasitological assays were performed before (Day 0) and after treatment (Days 7, 14, 21, and 28). All data were statistically analyzed by independent-sample -test or paired -test.

Results: In both groups, mean values of MDA were significantly reduced, while those of TAC were significantly elevated after treatment on days 7, 14, 21, and 28. These significant changes were reported after treatment between PTG and DTG in favor of DTG. Serum concentrations of MDA were significantly reduced, while those of TAC were significantly elevated for DTG treatment group when their values were compared with those of PTG either on days 7, 14, 21, or 28. Significant correlations were reported in PTG and DTG. Negative significant correlations were reported between fecal egg count (FEC) and each of whole blood picture indices (RBCS, Hb, and PCV), serum TAC and faecal egg count reduction percentage FECR%. A positive correlation was seen between FEC and MDA. MDA exhibited a negative correlation with both blood picture and TAC; hence, TAC was positively correlated with these blood picture indices in both PTG and DTG. In PTG, anthelmintic resistance () was present on days 7 and 14, while it was suspected () at day 21 then it was absent () at day 28. In DTG, anthelmintic resistance was suspected () on day 7, then it became absent () on days 14, 21, and 28 post therapy.

Conclusion: The immunological status of the infected donkeys had greatly improved after treatment. The therapeutic efficacy of injectable doramectin was more efficient than that of oral piperazine citrate in spp. infected donkeys.