Signal transducer and activator of transcription 4 (STAT4) G/T gene polymorphism in Egyptian systemic lupus erythematosus female patients,
Raafat, Inas I., Azab Noha A., Khorshied Mervat M., Yacoub Marium H., and Samy Lamees A.
, The Egyptian Rheumatologist, Volume 37, Number 2, p.75 - 80, (2015)
AbstractAbstractBackground Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with complex genetic inheritance. Many reports have provided evidence that signal transducer and activator of transcription-4 (STAT4) may participate in the pathogenesis of SLE. Aim of the work The aim was to investigate the clinical significance and possible association of \{STAT4\} (G/T) genetic polymorphism and the susceptibility to \{SLE\} in a cohort of Egyptian female patients. Patients and methods Sixty-five Egyptian \{SLE\} female patients and 100 age and sex-matched unrelated female healthy blood donors who served as controls, were included in the study. \{STAT4\} genotyping was performed by real time PCR-allelic discrimination technique. Results \{STAT4\} genotyping in patients revealed that 63.1% had GG, 32.3% \{GT\} and 6.15% wild (TT) genotype. There was a non-significant difference in the distribution of \{STAT4\} genotypes between patients and controls. Vasculitis, photosensitivity and lupus nephritis were significantly increased in patients with the homomutant (GG and TT) compared to heteromutant (GT) genotype (p = 0.0
