, vol. 23, issue 2, pp. e01803, 2026 Feb.
Skeletal muscle (SkM) accounts for 30%-40% of body mass. SkM is required for body movement, energy metabolism, and material metabolism, all of which directly impact human quality of life. This review traces the key medicinal plants used for alleviating skeletal muscle disorders (SkMDs), with a focus on lifestyle modifications and exercise. A comprehensive literature search was conducted using databases such as Google Scholar, Elsevier, Springer Nature, Wiley, PubMed, and EKB. SkMDs are a broad category of conditions that affect the muscles, bones, joints, and connective tissues, resulting in major impairments in movement, function, and quality of life. SkMDs affect more than 1.3 billion people worldwide and are a major cause of disability and economic hardship. Conventional therapy approaches, such as pharmaceutical interventions and surgical procedures, are typically limited by undesirable side effects, extended recovery times, and patient dissatisfaction, especially when focusing only on symptom relief. In response, complementary and alternative medicine, particularly medicinal herbs, has grown in popularity to improve SkMD management. Medicinal plants have a diverse range of pharmacologically active compounds with anti-inflammatory, analgesic, and antioxidant effects, making them promising additions to traditional treatments. Berberine, curcumin, resveratrol, quercetin, (-)-epicatechin, and ginsenosides have been reported to have potential in SkMDs. These compounds exert their effects through multiple mechanisms, such as enhancing muscle protein synthesis, reducing inflammation, and modulating hormones that influence muscle mass. Overall, the study emphasizes the ability of natural supplementation approaches to improve clinical outcomes, improve patient well-being, and provide a more sustainable model for treating SkMDs.
