Background: Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy due to compression of the median nerve as it travels through the wrist at the carpal tunnel. The function of the hand can be severely affected by the sole loss of sensibility of the hand even though motor function is normal. Until now there is no optimal physical therapy protocol for making patients with CTS satisfied with the functional outcomes therefore most of patients are refuge to surgical interference. Aim of Study: To investigate the efficacy of sensory re-education paradigm on pain intensity, symptom severity, and functional outcomes in carpal tunnel syndrome patients. Subjects and Methods: Thirty patients suffering from mild to moderate carpal tunnel syndrome were enrolled. They were randomly assigned into two equal groups. The study group (A): received sensory re-education paradigm in addition to a selected physical therapy program. The control group (B): received the same selected physical therapy program only. Pain intensity level was assessed by the visual analogue scale (VAS), symptom severity and functional outcomes were assessed by Boston Carpal Tunnel Syndrome Questionnaire (BCTQ). The assessment was done before and after twelve treatment sessions. Results: There was a statistically significant improvement in pain intensity, and symptom severity in both groups post treatment. There was a statistically significant improvement in functional status score post treatment only in group (A) (P<0.05). A significant difference was recorded between both groups in favor of the study group in functional status score post treatment (p<0.05). Conclusion: Adding Sensory re-education paradigm to traditional physical therapy is a beneficial rehabilitation program in improving the functional outcomes in patients with CTS
