This study was conducted on sixty adult albino rats in attempt to evaluate the effect of calcium, vitamink, low intensity laser therapy and their combination on the histopathlogical bony changes in induced osteoporosis. Ten rats were maintained on normal diet, the remaining fifty rats were divided into three groups. Group A was received no drug. Group B was received calcium and subjected to laser on right side. Group C was received calcium and vitamin K and subjected to laser on the right side