Sakr, H. I., A. A. Khowailed, S. S. Gaber, O. M. Ahmed, and A. N. Eesa, "Effect of mandarin peel extract on experimentally induced arthritis in male rats.", Archives of physiology and biochemistry, pp. 1-12, 2019. Abstract

Rheumatoid arthritis (RA) is associated with joint damage. For treatment, non-steroidal anti-inflammatory drugs (NSAIDs), steroidal agents, and immune-suppressants are used. Their side-effects require a safe and effective natural alternative. Thirty-six male albino rats, half kept under observation for 1 week (group I) and others for 2 weeks (group II) were used. Each group was subdivided into: normal (A), RA (B), and oral mandarin-peel extract (MPE) treated (C). Ankle diameter, serum levels of RF, interleukin (IL)-1β, TNFα, IL-4, IL-10, liver homogenates malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), and nitric oxide (NO) were measured together with the histopathological examination. MPE treatment was associated with increased serum IL-4, IL-10, liver homogenates GSH, and SOD, and decreased ankle diameter, serum RF, IL-1β, TNFα, liver homogenates MDA, NO, inflammatory cell infiltrate, and necrosis. Two weeks' treatment was better. MPE has useful effects in alleviating the disturbed ankle diameter, serum pro- and anti-inflammatory mediators, oxidative stress, and ankle joint histopathology in rheumatic rats.

Moussa, R. A., A. N. Eesa, Z. F. Abdallah, A. Abdelmeged, A. Mahran, and H. Bahaa, "Diagnostic Utility of Twist1, Ki-67, and E-Cadherin in Diagnosing Molar Gestations and Hydropic Abortions.", American journal of clinical pathology, vol. 149, issue 5, pp. 442-455, 2018. Abstract

Objectives: This study aims to assess whether the expression of Twist1, Ki-67, and E-cadherin can guide the differential diagnosis of complete hydatidiform mole (CHM), partial hydatidiform mole (PHM), and hydropic abortion (HA).

Methods: Differential expression of Twist1, Ki-67, and E-cadherin was analyzed in gestational products from 55 cases of CHM, PHM, and HA using immunohistochemistry. Prior to analysis, the studied cases were confirmed for their diagnosis by flow cytometric assessment of DNA ploidy and p57 immunostaining.

Results: Twist1 expression can distinguish CHM from PHM and HA with 100% sensitivity, 100%, specificity, 100% positive predictive value (PPV), and 100% negative predictive value (NPV). Furthermore, combined Ki-67 and E-cadherin expression could differentiate PHM and HA with 100% sensitivity, 93.3% specificity, 92.3% PPV, and 100% NPV.

Conclusions: Twist1 expression is a highly reliable marker for the diagnosis of CHM, where combined Ki-67 and E-cadherin immunoreactivity can distinguish PHM from nonmolar pregnancies.

Torky, H. A., A. Taha, H. Marie, E. El-Desouky, O. Raslan, A. A. Moussa, A. M. Ahmad, A. Abo-Louz, S. Zaki, T. Fares, et al., "Role of topical oxytocin in improving vaginal atrophy in postmenopausal women: a randomized, controlled trial.", Climacteric : the journal of the International Menopause Society, vol. 21, issue 2, pp. 174-178, 2018. Abstract

OBJECTIVE AND DESIGN: Prospective randomized controlled trial to test the effectiveness of topical oxytocin gel to improve vaginal atrophy in postmenopausal women.

PATIENTS AND METHODS: A total of 140 postmenopausal women presenting with vaginal atrophy and who satisfied the inclusion and exclusion criteria were randomized into two groups each of 70 patients; they received intravaginal oxytocin gel or placebo gel for 30 days. Serum estrogen level, visual, colposcopic and histological vaginal examination were performed before and after treatment.

RESULTS: Forty-seven out of 70 women in the oxytocin gel group improved after treatment and none in the placebo group (p = 0.001). Forty-five participants in the oxytocin group and seven in the placebo group reported relief of dyspareunia (p = 0.001). Thirty-four participants in the oxytocin group and seven in the placebo group reported relief of soreness (p = 0.001). There was no significant difference between the circulating levels of estradiol in both groups before and after treatment (p = 0.4 and 0.6 for the oxytocin group and the placebo group, respectively).

CONCLUSION: Oxytocin gel is useful in the restoration of the vaginal epithelium in cases of postmenopausal atrophic vaginitis. Further studies with a longer follow-up period are required to test the long-term effects of oxytocin as a treatment for vaginal atrophy.

Torky, H. A., A. Elshenawy, and A. Eesa, "Infiltrating Mammary Duct Adenocarcinoma in the Right Labia Majora Along the Milk-Line.", Zeitschrift fur Geburtshilfe und Neonatologie, vol. 221, issue 6, pp. 283-285, 2017. Abstract

Breast tissue rarely arises from the vulva and malignancy might develop in it. Thirty-eight-year-old woman presented with a suspicious ulcer in the right labia majora discovered accidently and removed by wide local excision. Histopathology revealed infiltrating mammary duct adenocarcinoma along the milk line. Immunohistochemistry was positive for estrogen and progesterone receptors and equivocal overexpression for HER2 protein with a score of 2+. Metastatic work-up was clear. Inguinal lymph nodes were enlarged and lymphadenectomy done which showed positive lymph nodes on the right side and none on the left. She is receiving adjuvant therapy. Mammary duct carcinoma along the nipple line is rare but should be considered when dealing with suspicious vulvar lesions.

Eesa, A. N., and A. M. Bassam, "Expression of E-cadherin and P-cadherin in Breast Carcinoma", Middle-East Journal of Scientific Research, vol. 23, issue 6, pp. 1012-1019, 2015. expression_of__e-cadherin_and_p-cadherin_in_breast_carcinoma.pdf
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