Abd El-Hack, M. E., S. S. Elnesr, M. Alagawany, A. Gado, A. E. Noreldin, and A. A. Gabr, "世界家禽学会誌 (WPSJ) の紹介 家禽用飼料資材として緑茶 (Camellia sinensis) およびエピガロカテキンガレート", 日本家禽学会誌, vol. 57, no. 2: 日本家禽学会, pp. J53–55, 2020. Abstract
n/a
Pietrowski, M. J., A. A. Gabr, S. Kozlov, D. Blum, A. Halle, and K. Carvalho, "Glial purinergic signaling in neurodegeneration", Frontiers in neurology, vol. 12: Frontiers Media SA, pp. 654850, 2021. Abstract
n/a
Alagawany, M., S. S. Elnesr, M. R. Farag, M. E. Abd El-Hack, R. A. Barkat, A. A. Gabr, M. A. Foda, A. E. Noreldin, A. F. Khafaga, K. El-Sabrout, et al., "Potential role of important nutraceuticals in poultry performance and health-A comprehensive review", Research in Veterinary Science, vol. 137: WB Saunders, pp. 9–29, 2021. Abstract
n/a
Abd El-Hack, M. E., S. S. Elnesr, M. Alagawany, A. Gado, A. E. Noreldin, and A. A. Gabr, "Impact of green tea (Camellia sinensis) and epigallocatechin gallate on poultry", World's Poultry Science Journal, vol. 76, no. 1: Taylor & Francis, pp. 49–63, 2020. Abstract
n/a
Lee, K. H., S. -jung Lee, H. J. Lee, G. E. Choi, Y. H. Jung, D. I. Kim, A. A. Gabr, J. M. Ryu, and H. J. Han, "Amyloid $\beta$1-42 (A$\beta$1-42) induces the CDK2-mediated phosphorylation of tau through the activation of the mTORC1 signaling pathway while promoting neuronal cell death", Frontiers in molecular neuroscience, vol. 10: Frontiers Media SA, pp. 229, 2017. Abstract
n/a
Gabr, A. A., H. J. Lee, X. Onphachanh, Y. H. Jung, J. S. Kim, C. W. Chae, and H. J. Han, "Ethanol-induced PGE2 up-regulates A$\beta$ production through PKA/CREB signaling pathway", Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, vol. 1863, no. 11: Elsevier, pp. 2942–2953, 2017. Abstract
n/a
Onphachanh, X., H. J. Lee, J. R. Lim, Y. H. Jung, J. S. Kim, C. W. Chae, S. -jung Lee, A. A. Gabr, and H. J. Han, "Enhancement of high glucose-induced PINK1 expression by melatonin stimulates neuronal cell survival: Involvement of MT2/Akt/NF-$ąppa$B pathway", Journal of Pineal Research, vol. 63, no. 2, pp. e12427, 2017. Abstract
n/a
Kim, D. I., K. H. Lee, A. A. Gabr, G. E. Choi, J. S. Kim, S. H. Ko, and H. J. Han, "A$\beta$-Induced Drp1 phosphorylation through Akt activation promotes excessive mitochondrial fission leading to neuronal apoptosis", Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, vol. 1863, no. 11: Elsevier, pp. 2820–2834, 2016. Abstract
n/a
Abd El-Hack, M. E., S. S. Elnesr, M. Alagawany, A. Gado, A. E. Noreldin, and A. A. Gabr, "Impact of green tea (Camellia sinensis) and epigallocatechin gallate on poultry", World's Poultry Science Journal, vol. 76, no. 1: Taylor & Francis, pp. 49–63, 2020. Abstract
n/a
Gabr, A. A., H. J. Lee, X. Onphachanh, Y. H. Jung, J. S. Kim, C. W. Chae, and H. J. Han, "Ethanol-induced PGEup-regulates Aβ production through PKA/CREB signaling pathway.", Biochimica et biophysica acta, vol. 1863, issue 11, pp. 2942-2953, 2017 Nov. Abstract

Ethanol abuse aggravates dementia-associated cognitive defects through the progression of Alzheimer's disease (AD) pathophysiology. Beta-site APP-cleaving enzyme 1 (BACE1) has been considered as a key regulator of AD pathogenesis by controlling amyloid beta peptide (Aβ) accumulation. In addition, previous studies reported that endoplasmic reticulum (ER) stress and neuroinflammation have been proposed in ethanol-induced neurodegeneration. Thus, we investigated the role of ER stress and PGE, a neuroinflammation mediator, in the ethanol-stimulated BACE1 expression and Aβ production. Using the human-derived neuroblastoma cell line SK-N-MC, the results show that ethanol up-regulated BACE1 expression in a dose-dependent manner. Ethanol stimulated reactive oxygen species (ROS) production, which induced CHOP expression and eIF2α phosphorylation. PBA (an ER stress inhibitor) attenuated the ethanol-increased cyclooxygenase-2 (COX-2) expression and PGEproduction. By using salubrinal (an eIF2α dephosphorylation inhibitor) or EIF2A siRNA, we found that eIF2α phosphorylation mediated the ethanol-induced COX-2 expression. In addition, COX-2-induced BACE1 up-regulation was abolished by NS-398 (a selective COX-2 inhibitor). And, PF-04418948 (an EP-2 receptor inhibitor) pretreatment reduced ethanol-induced PKA activation and CREB phosphorylation as well as ethanol-stimulated Aβ production. Furthermore, 14-22 amide (a PKA inhibitor) pretreatment or CREB1 siRNA transfection suppressed the ethanol-induced BACE1 expression. In conclusion, ethanol-induced eIF2α phosphorylation stimulates COX-2 expression and PGEproduction which induces the BACE1 expression and Aβ production via EP-2 receptor-dependent PKA/CREB pathway.