The expected upcoming shortage of fossil fuels and the affirmed legislations and restrictions to reduce CO2 emissions that typically emerged to society with burning fossil fuels have stimulated a global interest to secure alternative clean and efficient energy resources for next generations. In this regard, fuel cells appeared highly efficient, clean (little emissions), reliable, quiet, long-lasted, easily installed and moved, and economic. They are expected to provide electric power for electric vehicles and several portable and stationary daily-live activities. The fuel employed in this cell should pass a preliminary screening procedure to be suitable for these targeted applications. These criteria include the fuel availability, cost, toxicity, calorific value, storage, density, phase, water content, purity, security of supply, and carbon content. Hydrogen, for long time, has been the focus of fundamental and applied research from the production and storage prospective for potential applications in hydrogen fuel cells (HFCs). However, unfortunately, the hazardous associated with the storage and transportation of hydrogen has motivated a replacement with safer liquid fuels. The direct formic acid fuel cells (DFAFCs), utilizing formic acid (FA) as a fuel, have shown superiority over the traditional hydrogen and direct methanol fuel cells (DMFCs) in providing electricity for portable electronic devices. Nevertheless, DFAFCs experience a catalytic deactivation of the Pt catalyst employed for FA electro-oxidation (FAO). This results from the adsorption of poisoning CO intermediate, which results from the “non-faradaic” dissociation of FA at Pt surfaces at open circuit potential. This ultimately deteriorates the overall performance of DFAFC. My research group, in one of its interests, is working to overcome the CO poisoning in order to improve the overall performance of DFAFCs.