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2023
Mannaa M, S. AA, R. A. M. Shawky A, Hassan IM, and A. - S. A. M., "A novel surgical technique for treatment of cervical vertebral stenotic myelopathy (wobbler syndrome) in a filly.", J Equine Vet Sci. , pp. 104493, 2023.
Elfeky, S. A., A. El-Dissouky, S. M. Hussein, Sara R El-Kewaey, and G. El-Ghannam, "A novel terpolymer nanocomposite (carboxymethyl β-cyclodextrin–nano chitosan–glutaraldehyde) for the potential removal of a textile dye acid red 37 from wate", Frontiers in chemistry , vol. 11, 2023.
, A novel terpolymer nanocomposite (carboxymethyl β-cyclodextrin–nano chitosan–glutaraldehyde) for the potential removal of a textile dye acid red 37 from water, , 2023.
Darwish, M. I. M., A. M. Moustafa, A. M. Youssef, M. Mansour, A. I. Yousef, A. El Omri, H. H. Shawki, M. F. Mohamed, H. M. Hassaneen, and I. A. Abdelhamid, "Novel Tetrahydro-[1, 2, 4] triazolo [3, 4-a] isoquinoline Chalcones Suppress Breast Carcinoma through Cell Cycle Arrests and Apoptosis", Molecules, vol. 28, issue 8: MDPI, pp. 3338, 2023. Abstract
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Darwish, M. I. M., A. M. Moustafa, A. M. Youssef, M. Mansour, A. I. Yousef, A. El Omri, H. H. Shawki, M. F. Mohamed, H. M. Hassaneen, and I. A. Abdelhamid, "Novel Tetrahydro-[1, 2, 4] triazolo [3, 4-a] isoquinoline Chalcones Suppress Breast Carcinoma through Cell Cycle Arrests and Apoptosis", Molecules, vol. 28, issue 8: MDPI, pp. 3338, 2023. Abstract
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Sobh, E. A., M. A. Dahab, E. B. Elkaeed, B. A. Alsfouk, I. M. Ibrahim, A. M. Metwaly, and I. H. Eissa, "A novel thieno [2, 3-d] pyrimidine derivative inhibiting vascular endothelial growth factor receptor-2: A story of computer-aided drug discovery", Drug Development Research, vol. 84, no. 6: Wiley Online Library, pp. 1247–1265, 2023. Abstract
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El-Deeb, A. M., A. F. Mohamed, M. F. El-Yamany, and D. M. El-Tanbouly, "Novel trajectories of the NK1R antagonist aprepitant in rotenone-induced Parkinsonism-like symptoms in rats: Involvement of ERK5/KLF4/p62/Nrf2 signaling axis.", Chemico-biological interactions, vol. 380, pp. 110562, 2023. Abstract

Regulation of the interplay between autophagy and oxidative stress is vital in maintaining neuronal homeostasis during neurotoxicity. The interesting involvement of NK1 receptor (NK1R) in neurodegeneration has highlighted the value of investigating the neuroprotective effect of aprepitant (Aprep), an NK1R antagonist in Parkinson's disease (PD). This study was conducted to disclose Aprep's ability to modulate extracellular signal-regulated kinase 5/Krüppel-like factor 4 (ERK5/KLF4) cue as molecular signaling implicated in regulating autophagy and redox signaling in response to rotenone neurotoxicity. Rotenone (1.5 mg/kg) was administered on alternate days, and rats were given Aprep simultaneously with or without PD98059, an ERK inhibitor, for 21 days. Aprep ameliorated motor deficits as verified by restored histological features, and intact neurons count in SN and striata along with tyrosine hydroxylase immunoreactivity in SN. The molecular signaling of Aprep was illustrated by the expression of KLF4 following the phosphorylation of its upstream target, ERK5. Nuclear factor erythroid 2-related factor 2 (Nrf2) was up-regulated, shifting the oxidant/antioxidant balance towards the antioxidant side, as evidenced by elevated GSH and suppressed MDA levels. In parallel, Aprep noticeably reduced phosphorylated α-synuclein aggregates due to autophagy induction as emphasized by marked LC3II/LC3I elevation and p62 level reduction. These effects were diminished upon PD98059 pre-administration. In conclusion, Aprep showed neuroprotective effects against rotenone-induced PD, which may be partially attributed to the activation of the ERK5/KLF4 signaling pathway. It modulated p62-mediated autophagy and Nrf2 axis which act cooperatively to counter rotenone-associated neurotoxicity pointing to Aprep's prospect as a curious candidate in PD research.

Rahman, D. A. E., M. A. Fouad, H. A. Allam, E. R. Mohammed, and H. H. El-Zoheiry, "Novel VEGFR-2 inhibitors as antiangiogenic and apoptotic agents via paracrine and autocrine cascades: Design, synthesis, and biological evaluation ", Bioorganic Chemistry , vol. 139, pp. 106678-106697, 2023.
Rahman, A. D. E., M. A. Fouad, E. R. Mohammed, H. H. El-Zoheiry, and H. A. Allam, "Novel VEGFR-2 inhibitors as antiangiogenic and apoptotic agents via paracrine and autocrine cascades: Design, synthesis, and biological evaluation", Bioorganic Chemistry , vol. 139, pp. 106678, 2023. paper_19.pdf
Abdel-Rahman, D. E., M. A. Fouad, E. R. Mohammed, H. H. El-Zoheiry, and H. A. Allam, "Novel VEGFR-2 inhibitors as antiangiogenic and apoptotic agents via paracrine and autocrine cascades: Design, synthesis, and biological evaluation", Bioorg. Chem. , vol. 139, pp. 106678, 2023.
El-Lateef, H. A. M., M. M. Khalaf, M. Gouda, K. Shalabi, F. E. ‑T. Heakal, A. S. M. Al-Janabi, and S. Shaaban, "Novel water-soluble organoselenocyanates and symmetrical diselenides tethered N-succinanilate and N-maleanilate as corrosion inhibitors for reinforced steel in the simulated concrete pore solution", Construction and Building Materials, vol. 366, issue 22 February 2023, pp. 130135, 2023.
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Hassan, A. S., N. Alsadat, C. H. R. I. S. T. O. P. H. E. CHESNEAU, and A. W. Shawki, "A novel weighted family of probability distributions with applications to world natural gas, oil, and gold reserves", Mathematical Biosciences and Engineering, vol. 20, issue 11, pp. 19871–19911, 2023. length_biased_truncated_lomax_-g_family.pdf
Ashraf M. Mohamed, Mohamed N. El-Bayaa, Dina H. Elnaggar, Naglaa A. Abdel-Hafez, Salwa F. Mohamed, M. A.ElSayed, Eman S. Abou-Amra, M. M. Omran, and W. A. El-Sayed, "Novel [1,2,3]triazoles, [1,2,3]triazolo[4,5-d]Pyrimidines, and Some of Their Glycoside Derivatives: Synthesis and Molecular Modeling as Potential Apoptotic Antitumor Agents", Polycyclic Aromatic Compounds, , 2023.
Sayed, A., I. Elbalasy, and M. S. Mohamed, "Novel β-Carotene and Astaxanthin-Producing Marine Planococcus sp.: Insights into Carotenogenesis Regulation and Genetic Aspects", Applied Biochemistry and Biotechnology, vol. 195, issue 1: Springer, pp. 217-235, 2023. Abstract
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Elasheri, A., E. M. Elgallad, N. Parson, and X. - G. Chen, Nucleation and transformation of Zr-bearing dispersoids in Al–Mg–Si 6xxx alloys, , 2023.
Hefny, M. S., and K. Hassan, "NUMBERING SYSTEM IN THE ANCIENT EGYPTIAN DOCUMENTS", SHEDET , issue 10, pp. 48-68, 2023.
application/pdf iconnumbering_system_in_the_ancient_egyptian_documents.pdf
Akl, S. A. Y., A. N. Ismail, M. Abdelmoghni, and Y. A. Hegazy, "Numerical analysis of laterally loaded barrettes performance in cohesionless soils", Journal of Engineering and Applied Science, vol. 70, issue 1: Springer Berlin Heidelberg Berlin/Heidelberg, pp. 51, 2023. Abstract
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Yao, Z., M. Derikvand, M. S. Solari, J. Zhang, F. M. A. Altalbawy, A. H. D. Al-Khafaji, O. A. Akbari, D. Toghraie, and I. M. Mohammed, "Numerical assessment of the impacts of non-Newtonian nanofluid and hydrophobic surfaces on conjugate heat transfer and irreversibility in a silicon microchannel heat-sink", Journal of the Taiwan Institute of Chemical Engineers, vol. 142, pp. 104642-104652, 2023. 7-_journal_of_the_taiwan_institute_of_chemical_engineers.pdf
Abd-Elhameed, W. M., S. O. Alkhamisi, A. K. Amin, and Y. H. Youssri, "Numerical Contrivance for Kawahara-Type Differential Equations Based on Fifth-Kind Chebyshev Polynomials", Symmetry, vol. 15, no. 1, 2023. AbstractWebsite
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Abd-Elhameed, W. M., S. O. Al-Khamisi, A. K. Amin, and Y. H. Youssri, "Numerical contrivance for {K}awahara-type differential equations based on fifth-kind {C}hebyshev polynomials", Symmetry, vol. 15, no. 1, pp. 138, 2023. Abstract
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El-Bashar, R., M. F. O. Hameed, H. Abdelhamid, J. Dai, and S. S. A. Obayya, "Numerical Investigation of Si Nanowires Integrated Perovskite for Efficient Tandem Solar Cell", 2023 24th International Arab Conference on Information Technology (ACIT): IEEE, pp. 1-4, 2023. Abstract
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Gomaa, M. A., T. H. M. A. Kasem, O. A. Huzayyin, A. Schlenkhoff, and J. Sasaki, "Numerical simulation and PIV measurements of the wave-induced flow field near semi-circular breakwaters", SN Applied Sciences, vol. 5, no. 7: Springer, pp. 175, 2023. Abstract
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Gomaa, M. A., T. H. M. A. Kasem, O. A. Huzayyin, A. Schlenkhoff, and J. Sasaki, "Numerical simulation and PIV measurements of the wave-induced flow field near semi-circular breakwaters", SN Applied Sciences, vol. 5, no. 7, pp. 175, 2023. AbstractWebsite

Careful design of the high-tech semi-circular breakwaters (SBW), which are used for protection against sea waves, is essential to avoid the failure of these large-scale projects. An improved design tool adopting numerical simulations, complemented with experimental measurements is introduced. Unstructured boundary-fitted grids are used to model the curved SBW boundary accurately and resolve the flow adjacent to it. Experimental measurements based on Particle Image Velocimetry (PIV) are introduced and the numerically simulated velocity fields are validated. For the first time, the strong free surface deformation upstream of the SBW, termed trough-breaking, is reproduced numerically. The phenomenon is investigated in detail and its impact on several SBW advantages and stability is emphasized. The improved accuracy due to unstructured boundary-fitted grids complemented by the PIV data set, offers valuable prospects for performing complex designs and exploring future applications.

Sweilam, N. H., S. M. Al-Mekhlafi, R. G. Salama, and T. A. R. Assiri, "Numerical Simulation for a Hybrid Variable-Order Multi-Vaccination COVID-19 Mathematical Model", Symmetry, vol. 15, no. 4, 2023. AbstractWebsite
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ADEL, M., M. Khader, T. A. Assiri, and W. Kallel, "Numerical simulation for COVID-19 model using a multidomain spectral relaxation technique", Symmetry, vol. 15, issue 4, pp. 1-14, 2023. 39-_covid_19_symmetry_2023.pdf
application/pdf icon39-_covid_19_symmetry_2023.pdf
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