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2023
Mokhtar, H., A. A. Surour, M. K. Azer, M. Ren, and A. Said, "New insights into chemical and spectroscopic characterization of beryl mineralization related to leucogranites in the west Wadi El Gemal area, southern Eastern Desert of Egypt", Geochemistry, vol. Paper No.125980, 2023.
Mokhtar, H., A. A. Surour, M. K. Azer, M. Ren, and A. Said, New insights into chemical and spectroscopic characterization of beryl mineralization related to leucogranites in the west Wadi El Gemal area, southern Eastern Desert of Egypt, , Giza, Egypt, 2023.
Gendy, A. M., A. Soubh, M. R. Elnagar, E. Hamza, K. A. Ahmed, A. Aglan, A. E. El-Haddad, M. A. Farag, and H. M. El-Sadek, "New insights into the role of berberine against 3-nitropropionic acid-induced striatal neurotoxicity: Possible role of BDNF–TrkB–PI3K/Akt and NF-κB signaling ", Food and Chemical Toxicology, vol. 175 , pp. 113721, 2023.
Nabeh, O. A., "New insights on the impact of gut microbiota on premenstrual disorders. Will probiotics solve this mystery?", Life Sciences, vol. 321, 2023. 1-s2.0-s0024320523002400-main.pdf
Abdelall, Y. Y., "A New Inverse Pareto Distribution", Asian Journal of Probability and Statistics, vol. 21, issue 2, pp. 22-34, 2023.
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Muhammed, H. Z., E. M. Almetwally, and E. - S. A. El-Sherpieny, "A New Inverse Rayleigh Distribution with Applications of COVID-19 Data: Properties, Estimation Methods and Censored Sample", Electronic Journal of Applied Statistical Analysis, vol. 16, issue 2, pp. 449-472, 2023.
Zedan, I. A., M. M. Soliman, K. M. Elsayed, and H. M. Onsi, "A New Matching Strategy for SIFT Based Copy-Move Forgery Detection", International Journal of Intelligent Engineering and Systems, vol. 16, issue 4, pp. 422-435, 2023.
application/pdf iconA New Matching Strategy for SIFT Based Copy-Move Forgery Detection
Abdelkhalik, A., G. Makhlouf, H. Ameen, and A. A. El-Gamal, "A new multifunctional flame-retardant coating for cotton fabric to enhance smoke suppression, and UV shielding properties", Industrial Crops and Products, vol. 205, pp. 117469, 2023.
Saafan, A. A., V. Khadkikar, M. S. E. Moursi, and H. H. Zeineldin, "A New Multiport DC-DC Converter for DC Microgrid Applications", IEEE TRANSACTIONS ON INDUSTRY APPLICATIONS, vol. 59, issue 1, pp. 601-611, 2023.
Bokhtia, R. M., S. S. Panda, A. S. Girgis, N. Samir, M. F. Said, A. Abdelnaser, S. Nasr, M. S. Bekheit, A. S. Dawood, H. Sharma, et al., "New NSAID Conjugates as Potent and Selective COX-2 Inhibitors: Synthesis, Molecular Modeling and Biological Investigation.", Molecules (Basel, Switzerland), vol. 28, issue 4, 2023. Abstract

New sets of ibuprofen and indomethacin conjugates comprising triazolyl heterocycle were synthesized via click chemistry, adopting an optimized protocol through the molecular hybridization approach affording the targeted agents in good yields. The new non-steroidal anti-inflammatory drug (NSAID) conjugates were designed and synthesized and could be considered as potential drug candidates for the treatment of pain and inflammation. The anti-inflammatory properties were investigated for all the synthesized conjugates. Among 14 synthesized conjugates, four (, , , and ) were found to have significant anti-inflammatory properties potency 117.6%, 116.5%, 93.8%, and 109.1% in comparison to reference drugs ibuprofen (97.2%) and indomethacin (100%) in the rat paw edema carrageenan test without any ulcerogenic liability. The suppression effect of cytokines IL-6, TNF-α, and iNOS in addition to NO in the LPS-induced RAW264.7 cells supports the promising anti-inflammatory properties observed in the ibuprofen conjugates. In addition, several conjugates showed promising peripheral and central analgesic activity. The selectivity index (SI) of compound (23.096) indicates the significant efficacy and selectivity for COX-2 over COX-1. Molecular modeling (docking and QSAR) studies described the observed biological properties.

Abdelall, Y. Y., "New Odoma Distribution with Application to Cancer Data", Indian journal of Science and Technology , vol. 16, issue 11, pp. 839-849, 2023.
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Alzabut, J., S. R. Grace, and G. N. Chhatria, "New oscillation results for higher order nonlinear differential equations with a nonlinear neutral terms", J. Math. Computer Sci., vol. 28, pp. 294–305, 2023. Abstract
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Youssef, D., O. Fekry, A. Badr, A. Afify, and E. Hamed, "A new perspective on quantitative assessment of photodynamic therapy mediated hydrogel nanocomposite in wound healing using objective biospeckle and morphological local-gradient", Computers in Biology and Medicine, vol. 163, pp. 107196, 2023.
Youssef, D., O. Fekry, A. Badr, A. Afify, Nehal, and E. Hamed, A new perspective on quantitative assessment of photodynamic therapy mediated hydrogel nanocomposite in wound healing using objective biospeckle and morphological local-gradient, , 2023.
Shahin, I. G., K. O. Mohamed, A. T. Taher, M. M. Elsebaei, A. S. Mayhoub, A. S. M. A. A. E. KASSAB, and A. Elshewy, "New Phenylthiazoles: Design, Synthesis, and Biological Evaluation as Antibacterial, Antifungal, and Anti-COVID-19 Candidates", Chem. Biodiversity, vol. 20, pp. e202301143, 2023.
Shahin, I. G., K. O. Mohamed, A. T. Taher, M. M. Elsebaei, A. S. Mayhoub, A. S. M. A. A. E. KASSAB, and A. Elshewy, "New Phenylthiazoles: Design, Synthesis, and Biological Evaluation as Antibacterial, Antifungal, and Anti‐COVID‐19 Candidates", Chemistry & Biodiversity, 2023.
Mohamed, K. O., A. Taher, A. Kasab, A. R. Mayhoub, M. M. Elsebaei, A. Elshewy, and I. G. Shahin, "New Phenylthiazoles: Design, Synthesis, and Biological Evaluation as Antibacterial, Antifungal,and Anti-COVID-19 Candidates", chemistry & biodiversity, vol. 20, issue 11, pp. 1-12, 2023.
application/octet-stream iconchemistry__biodiversity_2023.
Fathy, R., E. Ragab, and K. A. Ali, "New polymeric matrix of polylactic acid/sodium alginate/carbon nanoparticles (PLA/SA/CNP) for efficient removal of methylene blue", Chemical Papers, vol. 77, no. 10: Springer International Publishing Cham, pp. 6203–6216, 2023. Abstract
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Kandile, N., M. Ali, A. T. Taher, and H. Mohamed, "New potential anti-SARS-CoV-2 and anti-cancer therapies of chitosan derivatives and its nanoparticles: Preparation and characterization", Arabian Journal of Chemistry, vol. 16, issue 5, pp. 104676, 2023.
El-Fakharany, Z. S., Y. M. Nissan, NadaKSedky, R. K. Arafa, and S. M. Abou-Seri, "New proapoptotic chemotherapeutic agents based on the quinolone-3-carboxamide scaffold acting by VEGFR-2 inhibition.", Scientific reports, vol. 13, issue 1, pp. 11346, 2023. Abstractzeinab_.pdf

In the current study, we designed and synthesized a series of new quinoline derivatives 10a-p as antiproliferative agents targeting cancer through inhibition of VEGFR-2. Preliminary molecular docking to assess the interactions of the designed derivatives with the binding site of VEGFR-2 (PDB code: 4ASD) displayed binding poses and interactions comparable to sorafenib. The synthesized compounds exhibited VEGFR-2 inhibitory activity with IC ranging from 36 nM to 2.23 μM compared to sorafenib (IC = 45 nM), where derivative 10i was the most potent. Additionally, the synthesized derivatives were evaluated in vitro for their cytotoxic activity against HepG2 cancer cell line. Seven compounds 10a, 10c, 10d, 10e, 10i, 10n and 10o (IC = 4.60, 4.14, 1.07, 0.88, 1.60, 2.88 and 2.76 μM respectively) displayed better antiproliferative activity than sorafenib (IC = 8.38 μM). Compound 10i was tested against Transformed Human Liver Epithelial-2 normal cell line (THLE-2) to evaluate its selective cytotoxicity. Furthermore, 10i, as a potent representative of the series, was assayed for its apoptotic activity and cell cycle kinetics' influence on HepG2, its effects on the gene expression of VEGFR-2, and protein expression of the apoptotic markers Caspase-7 and Bax. Compound 10i proved to have a potential role in apoptosis by causing significant increase in the early and late apoptotic quartiles, a remarkable activity in elevating the relative protein expression of Bax and Caspase-7 and a significant reduction of VEGFR-2 gene expression. Collectively, the obtained results indicate that compound 10i has a promising potential as a lead compound for the development of new anticancer agents.

Fadaly, W. A. A., T. H. Zidan, N. M. Kahk, F. E. A. Mohamed, M. M. Abdelhakeem, R. G. Khalil, and M. T. M. Nemr, "New Pyrazolyl-Thiazolidinone/Thiazole Derivatives as Celecoxib/Dasatinib Analogues with Selective COX-2, HER-2 and EGFR Inhibitory Effects: Design, Synthesis, Anti-inflammatory/Anti-proliferative Activities, Apoptosis, Molecular Modeling and ADME Studies.", Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 38, issue 1, pp. 2281262, 2023.
El‐Gazzar, Y. I., H. R. ghaiad, A. E. M. Kerdawy, R. F. George, H. H. Georgey, K. M. Youssef, and H. I. El‐Subbagh, "New quinazolinone‐based derivatives as DHFR/EGFR‐TK inhibitors: Synthesis, molecular modeling simulations, and anticancer activity", Archiv der Pharmazie, vol. 356, issue 1, pp. 2200417, 2023.
El‐Gazzar, Y. I., H. R. ghaiad, A. E. M. Kerdawy, R. F. George, H. H. Georgey, K. M. Youssef, and H. I. El‐Subbagh, "New quinazolinone‐based derivatives as DHFR/EGFR‐TK inhibitors: Synthesis, molecular modeling simulations, and anticancer activity", Archiv Der Pharmazie, vol. 356, pp. e2200417, 2023.
, "New quinazolinone‐based derivatives as DHFR/EGFR‐TK inhibitors: Synthesis, molecular modeling simulations, and anticancer activity", Archiv der Pharmazie, vol. 356 , pp. 2200417, 2023.
El‐Gazzar, Y. I., H. R. ghaiad, A. E. M. Kerdawy, R. F. George, H. H. Georgey, K. M. Youssef, and H. I. El‐Subbagh, "New quinazolinone‐based derivatives as DHFR/EGFR‐TK inhibitors: Synthesis, molecular modeling simulations, and anticancer activity", Archiv der Pharmazie, vol. 356 , pp. 2200417, 2023.