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2023
Nour El-Din, H. T., M. M. Elsebaie, N. S. Abutaleb, A. M. Kotb, A. S. Attia, M. N. Seleem, and A. S. Mayhoub, "Expanding the structure-activity relationships of alkynyl diphenylurea scaffold as promising antibacterial agents.", RSC medicinal chemistry, vol. 14, issue 2, pp. 367-377, 2023. Abstract

With the continuous and alarming threat of exhausting the current antimicrobial arsenals, efforts are urgently needed to develop new effective ones. In this study, the antibacterial efficacy of a set of structurally related acetylenic-diphenylurea derivatives carrying the aminoguanidine moiety was tested against a panel of multidrug-resistant Gram-positive clinical isolates. Compound 18 was identified with a superior bacteriological profile than the lead compound I. Compound 18 demonstrated an excellent antibacterial profile : low MIC values, extended post-antibiotic effect, refractory ability to resistance development upon extended repeated exposure, and high tolerability towards mammalian cells. Finally, when assessed in a MRSA skin infection animal model, compound 18 showed considerable healing and less inflammation, decrease in the bacterial loads in skin lesions, and it surpassed fusidic acid in controlling the systemic dissemination of . Collectively, compound 18 represents a promising lead anti-MRSA agent that merits further investigation for the development of new anti-staphylococcal therapeutics.

El-Din, H. N. T., M. M. Elsebaie, N. S. Abutaleb, A. M. Kotb, A. S. Attia, M. N. Seleem, and A. S. Mayhoub, "Expanding the structure–activity relationships of alkynyl diphenylurea scaffold as promising antibacterial agent", RSC Medicinal Chemistry, vol. 14, issue 22, pp. 367-377, 2023.
Medany, S. S., Y. H. Ahmad, and A. M. Fekry, "Experimental and theoretical studies for corrosion of molybdenum electrode using streptomycin drug in phosphoric acid medium", Scientific Reports, vol. 13, issue 1, pp. 4827, 2023.
ZAYED, R. E. D. A. A., L. F. Ibrahim, H. A. Hefny, H. A. Salman, and A. B. D. U. L. A. Z. I. Z. ALMOHIMEED, "Experimental and Theoretical Study for the Popular Shilling Attacks Detection Methods in Collaborative Recommender System", IEEE Access, vol. 11, pp. 79358-79369, 2023.
, "Experimental and Theoretical Study for the Popular Shilling Attacks Detection Methods in Collaborative Recommender System", IEEE Access, vol. 11, pp. 79358-79369, 2023. Abstract
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ZAYED, R. E. D. A. A., L. F. Ibrahim, H. A. Hefny, H. A. Salman, and A. B. D. U. L. A. Z. I. Z. ALMOHIMEED, "Experimental and Theoretical Study for the Popular Shilling Attacks Detection Methods in Collaborative Recommender System", IEEE ACCESS, vol. 11, pp. 79358-79369, 2023. experimental.pdf
Al-Shamiri, H., S. Melhi, E. Alosaimi, B.El-Gammal, H. Elhouichet, M. Sakr, A. M. Kana, and H. Kandel, "Experimental and theoretical study of optical properties of pyrromethene (PM-597) laser dye in binary eco-friendly solvent", J Phys Org Chem., vol. 36, issue 2, pp. 1-14, 2023. experimental_and_theoretical_study_of_optical_properties_of_pyrromethene_pm-597_laser_dye_in_binary_eco-friendly_solvent.pdf
Kana, M. A. T. H., "Experimental and theoretical study of optical properties of pyrromethene (PM-597) laser dye in binary eco-friendly solvent", J Phys Org Chem, 2023.
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Zaki, O. M., M. Sadek, H. Aly, and O. Abdelaziz, "Experimental assessment and modeling of radiant cooling technology using constant and variable water flow rate", Science and Technology for the Built Environment, vol. 29, no. 5: Taylor & Francis, pp. 560–573, 2023. Abstract
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Elsharkawy, L., M. A. Hegazy, A. E. El Gendy, and R. M. Ahmed, "Experimental Design Approach for Development of HPLC Method for Simultaneous Analysis of Triamcinolone, Nystatin, and Gramicidin in Industrial Wastewater", Separations, vol. 10, no. 6, 2023. AbstractWebsite
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Fayad, M. A., S. I. Ibrahim, S. H. Omran, F. J. Martos, T. Badawy, A. A. M. Jubori, H. A. Dhahad, and M. T. Chaichan, "Experimental effect of CuO2 nanoparticles into the RME and EGR rates on NOX and morphological characteristics of soot nanoparticles", Fuel, vol. 331, issue 125549, 2023.
Amer, M. M., F. HS, H. M. Mekky, E. KM, E. - S. A, and B. MA, "Experimental induction and control of cellulitis in broiler chickens.", Adv. Anim. Vet. Sci. , vol. 11, issue 9, pp. 1424-1440, 2023. experimental_induction_and_control_of_cellulitis.pdf
Husien, S., R. M. El-taweel, K. A. Alrefaey, A. Labena, I. S. Fahim, L. A. Said, and A. G. Radwan, "Experimental investigation of methyl-orange removal using eco-friendly cost-effective materials raw fava bean peels and their formulated physical, and chemically activated carbon", Current Research in Green and Sustainable Chemistry, vol. 7: Elsevier, pp. 100373, 2023. Abstract
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Abd-El-Aal, A., and A. Youssef, "Experimental investigation on corroded and non‑corroded RC tunnels under different loading conditions", Journal of Engineering and Applied Science, vol. 70, issue 146, pp. 1-30, 2023. s44147-023-00306-5.pdf
Saleh, M. M., S. H. M. Alagamawy, and A. N. Emam, "Experimental Study for Evaluating the Efficiency of Nanocomposites Materials for Biomicrite Limestone Consolidation", Egyptian Journal of Chemistry, vol. 13, issue SI, pp. 199 - 213, 2023.
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Eloriby, R. A. G., and hamdy mohamed mohamed, "An experimental study for using nano-alumina to improving mechanical properties of epoxy resin for assembling glass artifacts", Pigment & Resin Technology, 2023.
Zhao, Z., A. Huo, Y. Cheng, P. Luo, J. Peng, A. Elbeltagi, M. E. L. - S. Abuarab, and A. Mokhtar, "Experimental study on slope morphological characteristics and stability analysis of GCHP engineering in the loess plateau", Advances in Space Research, vol. 72, issue 10, pp. 4324-4335, 2023.
Ali, El Hadidi, N.M.N., Moussa, and Botros, W., "Experimental study to assess alternative supports for extensively deteriorated wooden Icons", Shedet, vol. 10, issue 10, pp. 261-278, 2023. shedet_volume_10_issue_10_pages_261-278.pdf
Nicoline F Post 1, Noah X Van Broekhoven 2, A. L. J. B. 2 M. 3, V. E. Marcel W Bekkenk 2, Caio C Silva de Castro 4, and N. G. I. H. G. L. 8 9 van Samia Esmat 6, Khaled Ezzedine 7, "Expert opinion about laser and intense pulsed light (IPL)-induced leukoderma or vitiligo: a cross-sectional survey study", Arch Dermatol Res . , vol. 315, issue 8, pp. 2289-2294. , 2023.
Zidan, M. S., M. M. El Sayed, A. F. Ismail, S. M. Ahmed, and H. E. Obaya, "Expiratory Muscle Training Versus Functional Electrical Stimulation on Pulmonary and Swallowing Functions in Acute Stroke Patients", Bulletin of Rehabilitation Medicine, vol. 22, issue 5, pp. 30-39, 2023.
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Moustafa, M., Y. H. Youssri, and A. G. Atta, "Explicit Chebyshev Petrov-Galerkin scheme for time-fractional fourth-order uniform Euler-Bernoulli pinned-pinned beam equation", Nonlinear Engineering, vol. 12, no. 1, 2023. AbstractWebsite
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Farghal, H. H., M. M. H. El-Sayed, and M. Nebsen, "Exploitation of expired cellulose biopolymers as hydrochars for capturing emerging contaminants from water", RSC advances, vol. 13, issue 29, pp. 19757-19769, 2023.
, "Exploitation of Modified Electrochemical Sensors for Fast and Reliable Detection of Plastics Endocrine-Disrupting Contaminants", Journal of The Electrochemical Society , vol. 170 , issue (12), , pp. 126504, 2023.
Amin, S. K., S. I. Hawash, M. F. Abadir, and S. A. Ghonaim, "Exploitation of rice agricultural wastes in clay masonry units preparation", ARPN Journal of Engineering and Applied Sciences, vol. 18, issue 11, pp. 1234-1248, 2023.
Marzouk, R., F. Alrowais, F. N. Al-Wesabi, and A. M. Hilal, "Exploiting Deep Learning Based Automated Fire-detection Model for Blind and Visually Challenged People", Journal of Disability Research, vol. 2, issue 4, pp. 50–57, 2023.
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